| pubmed-article:1623920 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1623920 | lifeskim:mentions | umls-concept:C0020204 | lld:lifeskim |
| pubmed-article:1623920 | lifeskim:mentions | umls-concept:C0877857 | lld:lifeskim |
| pubmed-article:1623920 | lifeskim:mentions | umls-concept:C0598666 | lld:lifeskim |
| pubmed-article:1623920 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:1623920 | lifeskim:mentions | umls-concept:C2702333 | lld:lifeskim |
| pubmed-article:1623920 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:1623920 | pubmed:dateCreated | 1992-8-11 | lld:pubmed |
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| pubmed-article:1623920 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1623920 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1623920 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1623920 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1623920 | pubmed:abstractText | The molecular mechanisms leading to anti-double-stranded (ds) DNA antibody production in systemic lupus erythematosus (SLE) are poorly understood. We describe here the immunoglobulin variable region genes of six human hybridomas secreting IgG anti-dsDNA antibodies derived from three SLE patients. The monoclonal IgG anti-dsDNA antibodies have been shown to be of high affinity and no multireactivity was observed (Winkler et al., Clin. Exp. Immunol., 1991. 85: 379). The comparison of the variable region genes expressed in the hybridomas with known germ-line genes as well as with the germ-line counterparts from one patient shows that the VH and VL sequences are somatically mutated. The pattern and extent of the observed somatic mutations are suggestive for an antigen-driven selection of at least four of these B cell clones. Several VH and VL genes used by the hybridomas were found to be expressed in the natural antibody repertoire, in the restricted fetal repertoire and in B cell malignancies expressing the CD5 antigen. | lld:pubmed |
| pubmed-article:1623920 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1623920 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1623920 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1623920 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1623920 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1623920 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:1623920 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:1623920 | pubmed:author | pubmed-author:KaldenJ RJR | lld:pubmed |
| pubmed-article:1623920 | pubmed:author | pubmed-author:FehrHH | lld:pubmed |
| pubmed-article:1623920 | pubmed:author | pubmed-author:WinklerT HTH | lld:pubmed |
| pubmed-article:1623920 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1623920 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:1623920 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1623920 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1623920 | pubmed:pagination | 1719-28 | lld:pubmed |
| pubmed-article:1623920 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1623920 | pubmed:meshHeading | pubmed-meshheading:1623920-... | lld:pubmed |
| pubmed-article:1623920 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1623920 | pubmed:articleTitle | Analysis of immunoglobulin variable region genes from human IgG anti-DNA hybridomas. | lld:pubmed |
| pubmed-article:1623920 | pubmed:affiliation | Department of Medicine III, University Erlangen-Nürnberg, FRG. | lld:pubmed |
| pubmed-article:1623920 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1623920 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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