| pubmed-article:16237164 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16237164 | lifeskim:mentions | umls-concept:C1457887 | lld:lifeskim |
| pubmed-article:16237164 | lifeskim:mentions | umls-concept:C0030567 | lld:lifeskim |
| pubmed-article:16237164 | lifeskim:mentions | umls-concept:C0382336 | lld:lifeskim |
| pubmed-article:16237164 | lifeskim:mentions | umls-concept:C0027746 | lld:lifeskim |
| pubmed-article:16237164 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:16237164 | lifeskim:mentions | umls-concept:C1521797 | lld:lifeskim |
| pubmed-article:16237164 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:16237164 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:16237164 | pubmed:issue | 42 | lld:pubmed |
| pubmed-article:16237164 | pubmed:dateCreated | 2005-10-20 | lld:pubmed |
| pubmed-article:16237164 | pubmed:abstractText | The opioid-like neuropeptide nociceptin/orphanin FQ (N/OFQ) and its receptor (NOP) are expressed in the substantia nigra (SN), a brain area containing dopamine neurons that degenerate in Parkinson's disease. Endogenous N/OFQ facilitates nigral glutamate release and inhibits nigrostriatal dopamine transmission and motor behavior. Here, we present evidence suggesting that endogenous N/OFQ may contribute to Parkinson's disease. Pharmacological blockade of the SN N/OFQ-NOP receptor system attenuated parkinsonian-like akinesia/hypokinesia in 6-hydroxydopamine hemilesioned or haloperidol-treated rats, whereas deletion of the NOP receptor gene conferred mice partial protection from haloperidol-induced motor depression. The antiparkinsonian action of NOP receptor antagonists was associated with reduction of glutamate release in the SN. In 6-hydroxydopamine hemilesioned rats, enhancement of N/OFQ expression and release was detected in the lesioned compared with the unlesioned SN, indicating that parkinsonism may be associated with overactivation of the N/OFQ-NOP receptor system in the SN. Finally, deletion of the N/OFQ gene conferred mice partial protection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced loss of SN dopamine neurons. Based on these data, we propose that NOP receptor antagonists may represent a novel approach for combined (symptomatic and neuroprotective) therapy of Parkinson's disease. | lld:pubmed |
| pubmed-article:16237164 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16237164 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16237164 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16237164 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16237164 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16237164 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16237164 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16237164 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16237164 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16237164 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16237164 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:16237164 | pubmed:author | pubmed-author:GuerriniRemoR | lld:pubmed |
| pubmed-article:16237164 | pubmed:author | pubmed-author:SalvadoriSeve... | lld:pubmed |
| pubmed-article:16237164 | pubmed:author | pubmed-author:BrownJeffrey... | lld:pubmed |
| pubmed-article:16237164 | pubmed:author | pubmed-author:RomualdiPatri... | lld:pubmed |
| pubmed-article:16237164 | pubmed:author | pubmed-author:CandelettiSan... | lld:pubmed |
| pubmed-article:16237164 | pubmed:author | pubmed-author:MartiMatteoM | lld:pubmed |
| pubmed-article:16237164 | pubmed:author | pubmed-author:MorariMichele... | lld:pubmed |
| pubmed-article:16237164 | pubmed:author | pubmed-author:SimonatoMiche... | lld:pubmed |
| pubmed-article:16237164 | pubmed:author | pubmed-author:BuzasBeataB | lld:pubmed |
| pubmed-article:16237164 | pubmed:author | pubmed-author:CoxBrian MBM | lld:pubmed |
| pubmed-article:16237164 | pubmed:author | pubmed-author:MelaFloraF | lld:pubmed |
| pubmed-article:16237164 | pubmed:author | pubmed-author:ZucchiniSilvi... | lld:pubmed |
| pubmed-article:16237164 | pubmed:author | pubmed-author:ReinscheidRai... | lld:pubmed |
| pubmed-article:16237164 | pubmed:author | pubmed-author:WittaJassirJ | lld:pubmed |
| pubmed-article:16237164 | pubmed:author | pubmed-author:Di... | lld:pubmed |
| pubmed-article:16237164 | pubmed:author | pubmed-author:FantinMartina... | lld:pubmed |
| pubmed-article:16237164 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16237164 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:16237164 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:16237164 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16237164 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16237164 | pubmed:pagination | 9591-601 | lld:pubmed |
| pubmed-article:16237164 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:16237164 | pubmed:meshHeading | pubmed-meshheading:16237164... | lld:pubmed |
| pubmed-article:16237164 | pubmed:meshHeading | pubmed-meshheading:16237164... | lld:pubmed |
| pubmed-article:16237164 | pubmed:meshHeading | pubmed-meshheading:16237164... | lld:pubmed |
| pubmed-article:16237164 | pubmed:meshHeading | pubmed-meshheading:16237164... | lld:pubmed |
| pubmed-article:16237164 | pubmed:meshHeading | pubmed-meshheading:16237164... | lld:pubmed |
| pubmed-article:16237164 | pubmed:meshHeading | pubmed-meshheading:16237164... | lld:pubmed |
| pubmed-article:16237164 | pubmed:meshHeading | pubmed-meshheading:16237164... | lld:pubmed |
| pubmed-article:16237164 | pubmed:meshHeading | pubmed-meshheading:16237164... | lld:pubmed |
| pubmed-article:16237164 | pubmed:meshHeading | pubmed-meshheading:16237164... | lld:pubmed |
| pubmed-article:16237164 | pubmed:meshHeading | pubmed-meshheading:16237164... | lld:pubmed |
| pubmed-article:16237164 | pubmed:meshHeading | pubmed-meshheading:16237164... | lld:pubmed |
| pubmed-article:16237164 | pubmed:meshHeading | pubmed-meshheading:16237164... | lld:pubmed |
| pubmed-article:16237164 | pubmed:meshHeading | pubmed-meshheading:16237164... | lld:pubmed |
| pubmed-article:16237164 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16237164 | pubmed:articleTitle | Blockade of nociceptin/orphanin FQ transmission attenuates symptoms and neurodegeneration associated with Parkinson's disease. | lld:pubmed |
| pubmed-article:16237164 | pubmed:affiliation | Department of Experimental and Clinical Medicine, Neuroscience Center, University of Ferrara, 44100 Ferrara, Italy. | lld:pubmed |
| pubmed-article:16237164 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16237164 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16237164 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:16237164 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16237164 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:18155 | entrezgene:pubmed | pubmed-article:16237164 | lld:entrezgene |
| entrez-gene:18389 | entrezgene:pubmed | pubmed-article:16237164 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16237164 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16237164 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16237164 | lld:pubmed |
