| pubmed-article:16237069 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16237069 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:16237069 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:16237069 | lifeskim:mentions | umls-concept:C0450127 | lld:lifeskim |
| pubmed-article:16237069 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:16237069 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:16237069 | lifeskim:mentions | umls-concept:C0522536 | lld:lifeskim |
| pubmed-article:16237069 | lifeskim:mentions | umls-concept:C1706856 | lld:lifeskim |
| pubmed-article:16237069 | lifeskim:mentions | umls-concept:C2728259 | lld:lifeskim |
| pubmed-article:16237069 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:16237069 | pubmed:dateCreated | 2005-10-20 | lld:pubmed |
| pubmed-article:16237069 | pubmed:abstractText | Although fully MHC-mismatched murine cardiac allografts are rapidly rejected, allografts mismatched at only MHC class I or class II alleles survive long term; the immunologic basis for the long-term survival of MHC class I- or II-mismatched allografts is unknown. We examined the roles of two recently described inhibitory receptors, B and T lymphocyte attenuator (BTLA) and programmed death-1 (PD-1), in the survival of partially or fully MHC-mismatched allografts using gene-deficient recipients as well as through use of blocking mAbs in wild-type hosts. Partially MHC-mismatched allografts showed strong induction of BTLA, but not PD-1 mRNA and survived long term in wild-type recipients, whereas targeting of BTLA or its ligand, herpesvirus entry mediator, but not PD-1, prompted their rapid rejection. By contrast, fully MHC-mismatched cardiac allografts were acutely rejected in wild-type recipients despite the induction of both BTLA and PD-1. Targeting of PD-1 in several fully MHC-mismatched models accelerated rejection, whereas targeting of BTLA unexpectedly enhanced PD-1 induction by alloreactive CD4 and CD8 T cells and prolonged allograft survival. In vitro studies using allogeneic dendritic cells and T cells showed that at low levels of T cell activation, BTLA expression was primarily induced, but that with increasing degrees of T cell activation, the expression of PD-1 was strongly up-regulated. These data suggest that BTLA and PD-1 exert distinct inhibitory actions in vivo, with the BTLA/herpesvirus entry mediator pathway appearing to dominate in regulating responses against a restricted degree of allogeneic mismatch. | lld:pubmed |
| pubmed-article:16237069 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16237069 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16237069 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16237069 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16237069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16237069 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16237069 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16237069 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:16237069 | pubmed:author | pubmed-author:SaeS WSW | lld:pubmed |
| pubmed-article:16237069 | pubmed:author | pubmed-author:HancockWayne... | lld:pubmed |
| pubmed-article:16237069 | pubmed:author | pubmed-author:MurphyKenneth... | lld:pubmed |
| pubmed-article:16237069 | pubmed:author | pubmed-author:YeQunruiQ | lld:pubmed |
| pubmed-article:16237069 | pubmed:author | pubmed-author:WangLiqingL | lld:pubmed |
| pubmed-article:16237069 | pubmed:author | pubmed-author:WangTaoT | lld:pubmed |
| pubmed-article:16237069 | pubmed:author | pubmed-author:MurphyTheresa... | lld:pubmed |
| pubmed-article:16237069 | pubmed:author | pubmed-author:HanRongxiangR | lld:pubmed |
| pubmed-article:16237069 | pubmed:author | pubmed-author:HonjoTakasuT | lld:pubmed |
| pubmed-article:16237069 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16237069 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16237069 | pubmed:volume | 175 | lld:pubmed |
| pubmed-article:16237069 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16237069 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16237069 | pubmed:pagination | 5774-82 | lld:pubmed |
| pubmed-article:16237069 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:16237069 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16237069 | pubmed:articleTitle | Differential effects of B and T lymphocyte attenuator and programmed death-1 on acceptance of partially versus fully MHC-mismatched cardiac allografts. | lld:pubmed |
| pubmed-article:16237069 | pubmed:affiliation | Division of Transplantation Immunology, Department of Pathology and Laboratory Medicine, Biesecker Pediatric Liver Center, Children's Hospital of Philadelphia, PA 19104, USA. | lld:pubmed |
| pubmed-article:16237069 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16237069 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:16237069 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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