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pubmed-article:16234608pubmed:abstractTextOrthostatic intolerance is a multifactorial disease in which the genetic contribution is probably the result of a number of genes acting in combination. Recent work has shown that orthostatic intolerance is influenced by endothelial nitric oxide synthase gene polymorphisms. Since endothelin-1 (ET-1) is one of the most important vasoconstrictor peptides, a frequent adenine insertion polymorphism within the 5'-untranslated region (5'UTR), which is of functional importance for ET-1 expression, could influence orthostatic intolerance. The aim of this study was therefore to ascertain whether this frequent variant of the endothelin-1 gene influences the risk for orthostatic intolerance.lld:pubmed
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pubmed-article:16234608pubmed:articleTitleInfluence of an insertion variant in the 5'UTR of the endothelin-1 gene on orthostatic intolerance.lld:pubmed
pubmed-article:16234608pubmed:affiliationDivision of Occupational Medicine, Medical University of Vienna, Vienna, Austria. robert.winker@meduniwien.ac.atlld:pubmed
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