| pubmed-article:16234315 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16234315 | lifeskim:mentions | umls-concept:C0008018 | lld:lifeskim |
| pubmed-article:16234315 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:16234315 | lifeskim:mentions | umls-concept:C0206522 | lld:lifeskim |
| pubmed-article:16234315 | lifeskim:mentions | umls-concept:C1285572 | lld:lifeskim |
| pubmed-article:16234315 | lifeskim:mentions | umls-concept:C1314763 | lld:lifeskim |
| pubmed-article:16234315 | lifeskim:mentions | umls-concept:C0012120 | lld:lifeskim |
| pubmed-article:16234315 | lifeskim:mentions | umls-concept:C1709016 | lld:lifeskim |
| pubmed-article:16234315 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:16234315 | pubmed:dateCreated | 2005-12-7 | lld:pubmed |
| pubmed-article:16234315 | pubmed:abstractText | MOTIVATION: Coordinate regulation of gene expression can provide information on gene function. To begin a large-scale analysis of Dictyostelium gene function, we clustered genes based on their expression in wild-type and mutant strains and analyzed their functions. RESULTS: We found 17 modes of wild-type gene expression and refined them into 57 submodes considering mutant data. Annotation analyses revealed correlations between co-expression and function and an unexpected correlation between expression and function of genes involved in various aspects of chemotaxis. Co-regulation of chemotaxis genes was also found in published data from neutrophils. To test the predictive power of the analysis, we examined the phenotypes of mutations in seven co-regulated genes that had no published role in chemotaxis. Six mutants exhibited chemotaxis defects, supporting the idea that function can be inferred from co-expression. The clustering and annotation analyses provide a public resource for Dictyostelium functional genomics. | lld:pubmed |
| pubmed-article:16234315 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16234315 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16234315 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16234315 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16234315 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16234315 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16234315 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16234315 | pubmed:issn | 1367-4803 | lld:pubmed |
| pubmed-article:16234315 | pubmed:author | pubmed-author:Van... | lld:pubmed |
| pubmed-article:16234315 | pubmed:author | pubmed-author:KuspaAdamA | lld:pubmed |
| pubmed-article:16234315 | pubmed:author | pubmed-author:ShaulskyGadG | lld:pubmed |
| pubmed-article:16234315 | pubmed:author | pubmed-author:BoothEzgi OEO | lld:pubmed |
| pubmed-article:16234315 | pubmed:author | pubmed-author:ZhuchenkoOlga... | lld:pubmed |
| pubmed-article:16234315 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16234315 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16234315 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:16234315 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16234315 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16234315 | pubmed:pagination | 4371-7 | lld:pubmed |
| pubmed-article:16234315 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:16234315 | pubmed:meshHeading | pubmed-meshheading:16234315... | lld:pubmed |
| pubmed-article:16234315 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16234315 | pubmed:articleTitle | Microarray phenotyping in Dictyostelium reveals a regulon of chemotaxis genes. | lld:pubmed |
| pubmed-article:16234315 | pubmed:affiliation | Graduate Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, TX 77030, USA. | lld:pubmed |
| pubmed-article:16234315 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16234315 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16234315 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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