| pubmed-article:16231040 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16231040 | lifeskim:mentions | umls-concept:C0664613 | lld:lifeskim |
| pubmed-article:16231040 | lifeskim:mentions | umls-concept:C1657248 | lld:lifeskim |
| pubmed-article:16231040 | lifeskim:mentions | umls-concept:C1269683 | lld:lifeskim |
| pubmed-article:16231040 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:16231040 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:16231040 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:16231040 | lifeskim:mentions | umls-concept:C1332098 | lld:lifeskim |
| pubmed-article:16231040 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16231040 | pubmed:dateCreated | 2005-12-15 | lld:pubmed |
| pubmed-article:16231040 | pubmed:abstractText | APAF1, encoding the protein apoptosis protease activating factor 1 (Apaf-1), has recently been established as a chromosome 12 gene conferring predisposition to major depression in humans. The molecular phenotypes of Apaf-1 variants were determined by in vitro reconstruction of the apoptosome complex in which Apaf-1 activates caspase 9 and thus initiates a cascade of proteolytic events leading to apoptotic destruction of the cell. Cellular phenotypes were measured using a yeast heterologous expression assay in which human Apaf-1 and other proteins necessary to constitute a functional apoptotic pathway were overexpressed. Apaf-1 variants encoded by APAF1 alleles that segregate with major depression in families linked to chromosome 12 shared a common gain-of-function phenotype in both assay systems. In contrast, other Apaf-1 variants showed neutral or loss-of-function phenotypes. The depression-associated alleles thus have a common phenotype that is distinct from that of non-associated variants. This result suggests an etiologic role for enhanced apoptosis in major depression. | lld:pubmed |
| pubmed-article:16231040 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16231040 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16231040 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16231040 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16231040 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16231040 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16231040 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16231040 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16231040 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:16231040 | pubmed:issn | 1359-4184 | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:HarlanJJ | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:JohnsonR WRW | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:OlsenTT | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:HahnAA | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:PotterJJ | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:DavenportCC | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:ChenYY | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:MetzgerPP | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:SpeakB MBM | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:BeckAA | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:WalterKK | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:LIENR MRM | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:ShattuckDD | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:MuellerRR | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:HalbertD NDN | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:SkolnickM HMH | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:SHURS GSG | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:Gopalakrishna... | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:LakeMM | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:EganD ADA | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:SullivanJ PJP | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:HolzmanT FTF | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:SeverinJJ | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:LafontM JMJ | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:GubbinsEE | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:NeffC DCD | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:AbkevichVV | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:DorwinSS | lld:pubmed |
| pubmed-article:16231040 | pubmed:author | pubmed-author:VoelpKK | lld:pubmed |
| pubmed-article:16231040 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16231040 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:16231040 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16231040 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16231040 | pubmed:pagination | 76-85 | lld:pubmed |
| pubmed-article:16231040 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16231040 | pubmed:meshHeading | pubmed-meshheading:16231040... | lld:pubmed |
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| pubmed-article:16231040 | pubmed:meshHeading | pubmed-meshheading:16231040... | lld:pubmed |
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| pubmed-article:16231040 | pubmed:meshHeading | pubmed-meshheading:16231040... | lld:pubmed |
| pubmed-article:16231040 | pubmed:meshHeading | pubmed-meshheading:16231040... | lld:pubmed |
| pubmed-article:16231040 | pubmed:meshHeading | pubmed-meshheading:16231040... | lld:pubmed |
| pubmed-article:16231040 | pubmed:meshHeading | pubmed-meshheading:16231040... | lld:pubmed |
| pubmed-article:16231040 | pubmed:meshHeading | pubmed-meshheading:16231040... | lld:pubmed |
| pubmed-article:16231040 | pubmed:meshHeading | pubmed-meshheading:16231040... | lld:pubmed |
| pubmed-article:16231040 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16231040 | pubmed:articleTitle | Variants in Apaf-1 segregating with major depression promote apoptosome function. | lld:pubmed |
| pubmed-article:16231040 | pubmed:affiliation | Advanced Technologies, Abbott Laboratories, 100 Abbott Park Road R424/AP10, Abbott Park, IL 60064, USA. | lld:pubmed |
| pubmed-article:16231040 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:317 | entrezgene:pubmed | pubmed-article:16231040 | lld:entrezgene |
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