| pubmed-article:16229947 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16229947 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:16229947 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:16229947 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:16229947 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16229947 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
| pubmed-article:16229947 | lifeskim:mentions | umls-concept:C0242606 | lld:lifeskim |
| pubmed-article:16229947 | lifeskim:mentions | umls-concept:C0007587 | lld:lifeskim |
| pubmed-article:16229947 | lifeskim:mentions | umls-concept:C0521390 | lld:lifeskim |
| pubmed-article:16229947 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:16229947 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:16229947 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:16229947 | pubmed:dateCreated | 2005-12-26 | lld:pubmed |
| pubmed-article:16229947 | pubmed:abstractText | Elucidating the relationship of glutamate-induced Ca2+ flux and oxidative death of neuronal cells may be of great relevance for neurodegenerative diseases in human beings. Mouse hippocampal HT22 cells provide a model system to study this relationship at the molecular level. Here we show that stimulation of HT22 cells with 5 mM glutamate is cytotoxic. Glutamate-induced cytotoxicity was associated with the generation of reactive oxygen species (ROS) and activation of the death executioner caspases 1 and 3. Treatment of HT22 cells with the calcium chelator, EGTA, and the calcium channel blocker, CoCl2, revealed that glutamate-induced cell death was dependent, in part, on glutamate-induced Ca2+ influx from extracellular stores. However, activation of caspases 1 and 3 and death of HT22 cells were also observed when Ca2+ was lacking in the extracellular milieu and ROS production abrogated. These findings led us to conclude that glutamate-induced death of mouse HT22 cells utilizes a complex mechanism that relies only in part on Ca2+ influx and ROS production. Additional studies are warranted to evaluate glutamate-induced death mechanisms that operate independently of Ca2+ influx and generation of ROS. | lld:pubmed |
| pubmed-article:16229947 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16229947 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16229947 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16229947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16229947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16229947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16229947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16229947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16229947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16229947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16229947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16229947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16229947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16229947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16229947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16229947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16229947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16229947 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16229947 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:16229947 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:16229947 | pubmed:author | pubmed-author:ParkSung... | lld:pubmed |
| pubmed-article:16229947 | pubmed:author | pubmed-author:HaJong... | lld:pubmed |
| pubmed-article:16229947 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16229947 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:16229947 | pubmed:volume | 393 | lld:pubmed |
| pubmed-article:16229947 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16229947 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16229947 | pubmed:pagination | 165-9 | lld:pubmed |
| pubmed-article:16229947 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16229947 | pubmed:meshHeading | pubmed-meshheading:16229947... | lld:pubmed |
| pubmed-article:16229947 | pubmed:meshHeading | pubmed-meshheading:16229947... | lld:pubmed |
| pubmed-article:16229947 | pubmed:meshHeading | pubmed-meshheading:16229947... | lld:pubmed |
| pubmed-article:16229947 | pubmed:meshHeading | pubmed-meshheading:16229947... | lld:pubmed |
| pubmed-article:16229947 | pubmed:meshHeading | pubmed-meshheading:16229947... | lld:pubmed |
| pubmed-article:16229947 | pubmed:meshHeading | pubmed-meshheading:16229947... | lld:pubmed |
| pubmed-article:16229947 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16229947 | pubmed:articleTitle | Glutamate-induced oxidative stress, but not cell death, is largely dependent upon extracellular calcium in mouse neuronal HT22 cells. | lld:pubmed |
| pubmed-article:16229947 | pubmed:affiliation | Systemic Proteomics Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 52 Oun, Yusong, Taejon 305-333, South Korea. | lld:pubmed |
| pubmed-article:16229947 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16229947 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16229947 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16229947 | lld:pubmed |
