| pubmed-article:16224061 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16224061 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16224061 | lifeskim:mentions | umls-concept:C0012155 | lld:lifeskim |
| pubmed-article:16224061 | lifeskim:mentions | umls-concept:C0034821 | lld:lifeskim |
| pubmed-article:16224061 | lifeskim:mentions | umls-concept:C0005847 | lld:lifeskim |
| pubmed-article:16224061 | lifeskim:mentions | umls-concept:C0023823 | lld:lifeskim |
| pubmed-article:16224061 | lifeskim:mentions | umls-concept:C0042401 | lld:lifeskim |
| pubmed-article:16224061 | lifeskim:mentions | umls-concept:C0085201 | lld:lifeskim |
| pubmed-article:16224061 | lifeskim:mentions | umls-concept:C1280412 | lld:lifeskim |
| pubmed-article:16224061 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:16224061 | lifeskim:mentions | umls-concept:C1705493 | lld:lifeskim |
| pubmed-article:16224061 | lifeskim:mentions | umls-concept:C0677535 | lld:lifeskim |
| pubmed-article:16224061 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:16224061 | pubmed:dateCreated | 2005-11-24 | lld:pubmed |
| pubmed-article:16224061 | pubmed:abstractText | Previously we showed L-4F, a novel apolipoprotein A-I (apoA-I) mimetic, improved vasodilation in 2 dissimilar models of vascular disease: hypercholesterolemic LDL receptor-null (Ldlr(-/-)) mice and transgenic sickle cell disease mice. Here we determine the mechanisms by which D-4F improves vasodilation and arterial wall thickness in hypercholesterolemic Ldlr(-/-) mice and Ldlr(-/-)/apoA-I null (apoA-I(-/-)), double-knockout mice. Ldlr(-/-) and Ldlr(-/-)/apoA-I(-/-) mice were fed Western diet (WD) with and without D-4F. Oral D-4F restored endothelium- and endothelial NO synthase (eNOS)-dependent vasodilation in direct relationship to duration of treatments and reduced wall thickness in as little as 2 weeks in vessels with preexisting disease in Ldlr(-/-) mice. D-4F had no effect on total or HDL cholesterol concentrations but reduced proinflammatory HDL levels. D-4F had no effect on plasma myeloperoxidase concentrations but reduced myeloperoxidase association with apoA-I as well as 3-nitrotyrosine in apoA-I. D-4F increased endothelium- and eNOS-dependent vasodilation in Ldlr(-/-)/apoA-I(-/-) mice but did not reduce wall thickness as it had in Ldlr(-/-) mice. Vascular endothelial cells were treated with 22(R)-hydroxycholesterol with and without L-4F. 22(R)-Hydroxycholesterol decreased NO (*NO) and increased superoxide anion (O2*-) production and increased ATP-binding cassette transporter-1 and collagen expression. L-4F restored *NO and O2*- balance, had little effect on ATP-binding cassette transporter-1 expression, but reduced collagen expression. These data demonstrate that although D-4F restores vascular endothelial cell and eNOS function to increase vasodilation, HDL containing apoA-I, or at least some critical concentration of the antiatherogenic lipoprotein, is required for D-4F to decrease vessel wall thickness. | lld:pubmed |
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| pubmed-article:16224061 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16224061 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16224061 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16224061 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16224061 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16224061 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16224061 | pubmed:issn | 1524-4571 | lld:pubmed |
| pubmed-article:16224061 | pubmed:author | pubmed-author:Sorci-ThomasM... | lld:pubmed |
| pubmed-article:16224061 | pubmed:author | pubmed-author:XuHaoH | lld:pubmed |
| pubmed-article:16224061 | pubmed:author | pubmed-author:WangJingliJ | lld:pubmed |
| pubmed-article:16224061 | pubmed:author | pubmed-author:OuJingsongJ | lld:pubmed |
| pubmed-article:16224061 | pubmed:author | pubmed-author:PritchardKirk... | lld:pubmed |
| pubmed-article:16224061 | pubmed:author | pubmed-author:KaulSushmaS | lld:pubmed |
| pubmed-article:16224061 | pubmed:author | pubmed-author:OuZhijunZ | lld:pubmed |
| pubmed-article:16224061 | pubmed:author | pubmed-author:OldhamKeith... | lld:pubmed |
| pubmed-article:16224061 | pubmed:author | pubmed-author:JonesDeron... | lld:pubmed |
| pubmed-article:16224061 | pubmed:author | pubmed-author:SignorinoPaul... | lld:pubmed |
| pubmed-article:16224061 | pubmed:author | pubmed-author:DensmoreJohn... | lld:pubmed |
| pubmed-article:16224061 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16224061 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:16224061 | pubmed:volume | 97 | lld:pubmed |
| pubmed-article:16224061 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16224061 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16224061 | pubmed:pagination | 1190-7 | lld:pubmed |
| pubmed-article:16224061 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:16224061 | pubmed:meshHeading | pubmed-meshheading:16224061... | lld:pubmed |
| pubmed-article:16224061 | pubmed:meshHeading | pubmed-meshheading:16224061... | lld:pubmed |
| pubmed-article:16224061 | pubmed:meshHeading | pubmed-meshheading:16224061... | lld:pubmed |
| pubmed-article:16224061 | pubmed:meshHeading | pubmed-meshheading:16224061... | lld:pubmed |
| pubmed-article:16224061 | pubmed:meshHeading | pubmed-meshheading:16224061... | lld:pubmed |
