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pubmed-article:16204299pubmed:abstractTextIn vitro, cold-induced injury is an important contributor to renal tubular cell damage. It is mediated by iron-dependent formation of reactive oxygen species and can be prevented by iron chelation. We studied whether iron chelators can prevent cold-induced damage in the isolated perfused rat kidney (IPK) model both after cold perfusion (CP) and after cold storage (CS). We hypothesized that in the CP model iron-dependent cold-induced injury is more pronounced, since oxygen is constantly provided.lld:pubmed
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pubmed-article:16204299pubmed:articleTitleIron chelators do not reduce cold-induced cell injury in the isolated perfused rat kidney model.lld:pubmed
pubmed-article:16204299pubmed:affiliationDepartment of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.lld:pubmed
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