Linked Life Data

16198563

Source:http://linkedlifedata.com/resource/pubmed/id/16198563

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:16198563rdf:typepubmed:Citationlld:pubmed
pubmed-article:16198563lifeskim:mentionsumls-concept:C0001369lld:lifeskim
pubmed-article:16198563lifeskim:mentionsumls-concept:C0014994lld:lifeskim
pubmed-article:16198563lifeskim:mentionsumls-concept:C0030016lld:lifeskim
pubmed-article:16198563lifeskim:mentionsumls-concept:C0040958lld:lifeskim
pubmed-article:16198563lifeskim:mentionsumls-concept:C0444626lld:lifeskim
pubmed-article:16198563lifeskim:mentionsumls-concept:C0441655lld:lifeskim
pubmed-article:16198563lifeskim:mentionsumls-concept:C0220781lld:lifeskim
pubmed-article:16198563lifeskim:mentionsumls-concept:C1883254lld:lifeskim
pubmed-article:16198563lifeskim:mentionsumls-concept:C0043309lld:lifeskim
pubmed-article:16198563lifeskim:mentionsumls-concept:C0243077lld:lifeskim
pubmed-article:16198563lifeskim:mentionsumls-concept:C0205460lld:lifeskim
pubmed-article:16198563lifeskim:mentionsumls-concept:C0243072lld:lifeskim
pubmed-article:16198563lifeskim:mentionsumls-concept:C0204514lld:lifeskim
pubmed-article:16198563pubmed:issue23lld:pubmed
pubmed-article:16198563pubmed:dateCreated2005-10-19lld:pubmed
pubmed-article:16198563pubmed:abstractTextA structure-based approach has been taken to develop 4'-substituted analogs of triclosan that target the key malarial enzyme Plasmodium falciparum enoyl acyl carrier protein reductase (PfENR). Many of these compounds exhibit nanomolar potency against purified PfENR enzyme and modest (2-10microM) potency against in vitro cultures of drug-resistant and drug-sensitive strains of the P. falciparum parasite. X-ray crystal structures of nitro 29, aniline 30, methylamide 37, and urea 46 demonstrate the presence of hydrogen-bonding interactions with residues in the active site and point to future rounds of optimization to improve compound potency against purified enzyme and intracellular parasites.lld:pubmed
pubmed-article:16198563pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16198563pubmed:languageenglld:pubmed
pubmed-article:16198563pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16198563pubmed:citationSubsetIMlld:pubmed
pubmed-article:16198563pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16198563pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16198563pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16198563pubmed:statusMEDLINElld:pubmed
pubmed-article:16198563pubmed:monthDeclld:pubmed
pubmed-article:16198563pubmed:issn0960-894Xlld:pubmed
pubmed-article:16198563pubmed:authorpubmed-author:SacchettiniJa...lld:pubmed
pubmed-article:16198563pubmed:authorpubmed-author:FidockDavid...lld:pubmed
pubmed-article:16198563pubmed:authorpubmed-author:JacobsWilliam...lld:pubmed
pubmed-article:16198563pubmed:authorpubmed-author:KuoMackMlld:pubmed
pubmed-article:16198563pubmed:authorpubmed-author:YuMinMlld:pubmed
pubmed-article:16198563pubmed:authorpubmed-author:AndersonJohn...lld:pubmed
pubmed-article:16198563pubmed:authorpubmed-author:JacobusDavid...lld:pubmed
pubmed-article:16198563pubmed:authorpubmed-author:SarantakisDim...lld:pubmed
pubmed-article:16198563pubmed:authorpubmed-author:SchiehserGuy...lld:pubmed
pubmed-article:16198563pubmed:authorpubmed-author:ShiehHong-Min...lld:pubmed
pubmed-article:16198563pubmed:authorpubmed-author:FreundlichJoe...lld:pubmed
pubmed-article:16198563pubmed:authorpubmed-author:ValderramosJu...lld:pubmed
pubmed-article:16198563pubmed:authorpubmed-author:LucumiEdinson...lld:pubmed
pubmed-article:16198563pubmed:issnTypePrintlld:pubmed
pubmed-article:16198563pubmed:day1lld:pubmed
pubmed-article:16198563pubmed:volume15lld:pubmed
pubmed-article:16198563pubmed:ownerNLMlld:pubmed
pubmed-article:16198563pubmed:authorsCompleteYlld:pubmed
pubmed-article:16198563pubmed:pagination5247-52lld:pubmed
pubmed-article:16198563pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:16198563pubmed:meshHeadingpubmed-meshheading:16198563...lld:pubmed
pubmed-article:16198563pubmed:meshHeadingpubmed-meshheading:16198563...lld:pubmed
pubmed-article:16198563pubmed:meshHeadingpubmed-meshheading:16198563...lld:pubmed
pubmed-article:16198563pubmed:meshHeadingpubmed-meshheading:16198563...lld:pubmed
pubmed-article:16198563pubmed:meshHeadingpubmed-meshheading:16198563...lld:pubmed
pubmed-article:16198563pubmed:meshHeadingpubmed-meshheading:16198563...lld:pubmed
pubmed-article:16198563pubmed:meshHeadingpubmed-meshheading:16198563...lld:pubmed
pubmed-article:16198563pubmed:year2005lld:pubmed
pubmed-article:16198563pubmed:articleTitleSynthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives.lld:pubmed
pubmed-article:16198563pubmed:affiliationDepartment of Medicinal Chemistry, Jacobus Pharmaceutical Company, 37 Cleveland Lane, Princeton, NJ 08540, USA. j_freundlich@jacobuspharm.comlld:pubmed
pubmed-article:16198563pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16198563pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...http://linkedlifedata.com/r...pubmed-article:16198563lld:chembl
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16198563lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16198563lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16198563lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16198563lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16198563lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16198563lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16198563lld:pubmed