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pubmed-article:16189095pubmed:abstractTextA chromosomally encoded oxacillinase, OXA-69, was characterized from Acinetobacter baumannii AYE. beta-Lactamase OXA-69 shared 97% amino acid identity with the recently described OXA-51 enzyme of A. baumannii and 62 and 56% amino acid identity with the carbapenem-hydrolyzing oxacillinases OXA-24 and OXA-23, respectively. Biochemical characterization of the purified OXA-69 revealed a narrow-spectrum hydrolysis profile but including, at a low level, imipenem and meropenem. By PCR and sequencing bla(OXA-69)-like genes were identified in all A. baumannii strains tested (n = 12), suggesting that this oxacillinase is naturally occurring in that species.lld:pubmed
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pubmed-article:16189095pubmed:articleTitleCharacterization of the naturally occurring oxacillinase of Acinetobacter baumannii.lld:pubmed
pubmed-article:16189095pubmed:affiliationService de Bactériologie-Virologie, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France.lld:pubmed
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