| pubmed-article:16189088 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16189088 | lifeskim:mentions | umls-concept:C0021288 | lld:lifeskim |
| pubmed-article:16189088 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16189088 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:16189088 | lifeskim:mentions | umls-concept:C0038170 | lld:lifeskim |
| pubmed-article:16189088 | lifeskim:mentions | umls-concept:C0086045 | lld:lifeskim |
| pubmed-article:16189088 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:16189088 | lifeskim:mentions | umls-concept:C0021027 | lld:lifeskim |
| pubmed-article:16189088 | lifeskim:mentions | umls-concept:C0036043 | lld:lifeskim |
| pubmed-article:16189088 | lifeskim:mentions | umls-concept:C1096776 | lld:lifeskim |
| pubmed-article:16189088 | lifeskim:mentions | umls-concept:C1516048 | lld:lifeskim |
| pubmed-article:16189088 | lifeskim:mentions | umls-concept:C1722614 | lld:lifeskim |
| pubmed-article:16189088 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:16189088 | pubmed:dateCreated | 2005-9-28 | lld:pubmed |
| pubmed-article:16189088 | pubmed:abstractText | Nosocomial or late-onset sepsis is a common complication among premature infants, with a frequency inversely correlated with birth weight. Increased susceptibility to infection is due in part to an immature humoral (antibody-mediated) immune response. This study investigated the pharmacokinetics (PKs) and safety of a donor-selected specific intravenous immune globulin (IVIG) preparation, INH-A21 (Veronate), for prevention of sepsis in premature infants. Thirty-six infants weighing between 500 and 1,250 g during the first postnatal week were eligible to begin a series of up to four intravenous infusions of 500 or 750 mg/kg of body weight INH-A21. Blood samples were analyzed for antibodies against the Ser-Asp dipeptide repeat G (SdrG) and clumping factor A (ClfA) surface proteins of staphylococci. Sparse sampling and population PK analyses were performed to derive PK parameters. Following administration of the 500- and 750-mg/kg doses, the estimated average steady-state levels of anti-ClfA were 6.1 U/ml and 9.2 U/ml, respectively, and those of anti-SdrG were 5.2 U/ml and 7.7 U/ml, respectively. The elimination half-lives for anti-ClfA and anti-SdrG were 719 h and 701 h, respectively, and the clearances were 0.18 ml/h and 0.21 ml/h, respectively. In the final model, the values of the PK parameters were independent of gestational age. Both doses of INH-A21 were well tolerated, and the safety profile was similar to those of other IVIG preparations. These results suggest that a shorter dosing interval should be utilized between the first and second doses to achieve and maintain higher titers of anti-ClfA and anti-SdrG antibodies. Further studies examining INH-A21 for the prevention of late-onset sepsis in infants within the weight range studied are warranted. | lld:pubmed |
| pubmed-article:16189088 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16189088 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16189088 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16189088 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16189088 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16189088 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16189088 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16189088 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16189088 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16189088 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16189088 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16189088 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16189088 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16189088 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16189088 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16189088 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16189088 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16189088 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16189088 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16189088 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16189088 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16189088 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16189088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16189088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16189088 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16189088 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16189088 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:16189088 | pubmed:author | pubmed-author:HetheringtonS... | lld:pubmed |
| pubmed-article:16189088 | pubmed:author | pubmed-author:SchelonkaRobe... | lld:pubmed |
| pubmed-article:16189088 | pubmed:author | pubmed-author:CapparelliEdm... | lld:pubmed |
| pubmed-article:16189088 | pubmed:author | pubmed-author:WhiteRobert... | lld:pubmed |
| pubmed-article:16189088 | pubmed:author | pubmed-author:BloomBarry... | lld:pubmed |
| pubmed-article:16189088 | pubmed:author | pubmed-author:OelbergDavid... | lld:pubmed |
| pubmed-article:16189088 | pubmed:author | pubmed-author:PearlmanSteph... | lld:pubmed |
| pubmed-article:16189088 | pubmed:author | pubmed-author:KueserTom JTJ | lld:pubmed |
| pubmed-article:16189088 | pubmed:author | pubmed-author:BifanoEllen... | lld:pubmed |
| pubmed-article:16189088 | pubmed:author | pubmed-author:PattiJosephJ | lld:pubmed |
| pubmed-article:16189088 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16189088 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:16189088 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16189088 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16189088 | pubmed:pagination | 4121-7 | lld:pubmed |
| pubmed-article:16189088 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:16189088 | pubmed:meshHeading | pubmed-meshheading:16189088... | lld:pubmed |
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| pubmed-article:16189088 | pubmed:meshHeading | pubmed-meshheading:16189088... | lld:pubmed |
| pubmed-article:16189088 | pubmed:meshHeading | pubmed-meshheading:16189088... | lld:pubmed |
| pubmed-article:16189088 | pubmed:meshHeading | pubmed-meshheading:16189088... | lld:pubmed |
| pubmed-article:16189088 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16189088 | pubmed:articleTitle | Multicenter study to determine antibody concentrations and assess the safety of administration of INH-A21, a donor-selected human Staphylococcal immune globulin, in low-birth-weight infants. | lld:pubmed |
| pubmed-article:16189088 | pubmed:affiliation | Trials-by-Design LLC, San Diego, California, USA. | lld:pubmed |
| pubmed-article:16189088 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16189088 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16189088 | lld:pubmed |
