| pubmed-article:16186819 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16186819 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16186819 | lifeskim:mentions | umls-concept:C0530678 | lld:lifeskim |
| pubmed-article:16186819 | lifeskim:mentions | umls-concept:C1519316 | lld:lifeskim |
| pubmed-article:16186819 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:16186819 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:16186819 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:16186819 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:16186819 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:16186819 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:16186819 | pubmed:dateCreated | 2005-10-5 | lld:pubmed |
| pubmed-article:16186819 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16186819 | pubmed:abstractText | Thrombospondins (THBSs) are secreted glycoproteins that have key roles in interactions between cells and the extracellular matrix. Here, we describe the 2.6-A-resolution crystal structure of the glycosylated signature domain of human THBS2, which includes three epidermal growth factor-like modules, 13 aspartate-rich repeats and a lectin-like module. These elements interact extensively to form three structural regions termed the stalk, wire and globe. The THBS2 signature domain is stabilized by these interactions and by a network of 30 bound Ca(2+) ions and 18 disulfide bonds. The structure suggests how genetic alterations of THBSs result in disease. | lld:pubmed |
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| pubmed-article:16186819 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16186819 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16186819 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16186819 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16186819 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16186819 | pubmed:issn | 1545-9993 | lld:pubmed |
| pubmed-article:16186819 | pubmed:author | pubmed-author:AnnisDouglas... | lld:pubmed |
| pubmed-article:16186819 | pubmed:author | pubmed-author:MosherDeane... | lld:pubmed |
| pubmed-article:16186819 | pubmed:author | pubmed-author:MisenheimerTi... | lld:pubmed |
| pubmed-article:16186819 | pubmed:author | pubmed-author:HannahBlue-le... | lld:pubmed |
| pubmed-article:16186819 | pubmed:author | pubmed-author:BernsteinDoug... | lld:pubmed |
| pubmed-article:16186819 | pubmed:author | pubmed-author:KeckJames LJL | lld:pubmed |
| pubmed-article:16186819 | pubmed:author | pubmed-author:CarlsonC... | lld:pubmed |
| pubmed-article:16186819 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16186819 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:16186819 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16186819 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16186819 | pubmed:pagination | 910-4 | lld:pubmed |
| pubmed-article:16186819 | pubmed:dateRevised | 2010-12-3 | lld:pubmed |
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| pubmed-article:16186819 | pubmed:meshHeading | pubmed-meshheading:16186819... | lld:pubmed |
| pubmed-article:16186819 | pubmed:meshHeading | pubmed-meshheading:16186819... | lld:pubmed |
| pubmed-article:16186819 | pubmed:meshHeading | pubmed-meshheading:16186819... | lld:pubmed |
| pubmed-article:16186819 | pubmed:meshHeading | pubmed-meshheading:16186819... | lld:pubmed |
| pubmed-article:16186819 | pubmed:meshHeading | pubmed-meshheading:16186819... | lld:pubmed |
| pubmed-article:16186819 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16186819 | pubmed:articleTitle | Structure of the calcium-rich signature domain of human thrombospondin-2. | lld:pubmed |
| pubmed-article:16186819 | pubmed:affiliation | Department of Medicine, 4285B Medical Sciences Center, University of Wisconsin-Madison, 1300 University Avenue, Madison, Wisconsin 53706, USA. | lld:pubmed |
| pubmed-article:16186819 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16186819 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:16186819 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16186819 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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