| pubmed-article:1618233 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1618233 | lifeskim:mentions | umls-concept:C0597198 | lld:lifeskim |
| pubmed-article:1618233 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:1618233 | lifeskim:mentions | umls-concept:C0032743 | lld:lifeskim |
| pubmed-article:1618233 | lifeskim:mentions | umls-concept:C0034605 | lld:lifeskim |
| pubmed-article:1618233 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1618233 | pubmed:dateCreated | 1992-8-6 | lld:pubmed |
| pubmed-article:1618233 | pubmed:abstractText | Clinical utilisation of positron emission tomography could be enhanced by the availability of short-lived radionuclides derived from generator systems. The zinc-62/copper-62 combination is one such system which could be used as a source for a number of copper-62 radiopharmaceuticals. We have developed and optimised a high activity (5.6 GBq, 150 mCi) zinc-62/copper-62 generator to provide 62Cu in a form that is suitable for direct labelling of pyruvaldehyde-bis-(N4-methylthiosemicarbazone)-copper(II), Cu(PTSM). The distribution coefficients of Zn(II) and Cu(II) between anion-exchange resin and various hydrochloric acid/organic solvent mixtures were measured. Based on these measurements a generator eluent of 0.3 M HCl/40% ethanol provided 62Cu in greater than 90% yield in a 3-ml volume. A very low 62Zn breakthrough of less than 3 x 10(-7)% was achieved. Copper-PTSM was successfully labelled with the no-carrier-added 62Cu eluent directly from the generator with 94% radiochemical yield. | lld:pubmed |
| pubmed-article:1618233 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1618233 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1618233 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1618233 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1618233 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1618233 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1618233 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1618233 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1618233 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1618233 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1618233 | pubmed:issn | 0340-6997 | lld:pubmed |
| pubmed-article:1618233 | pubmed:author | pubmed-author:SharmaH LHL | lld:pubmed |
| pubmed-article:1618233 | pubmed:author | pubmed-author:CoxMM | lld:pubmed |
| pubmed-article:1618233 | pubmed:author | pubmed-author:LeoN WNW | lld:pubmed |
| pubmed-article:1618233 | pubmed:author | pubmed-author:GoodallRR | lld:pubmed |
| pubmed-article:1618233 | pubmed:author | pubmed-author:BabichJ WJW | lld:pubmed |
| pubmed-article:1618233 | pubmed:author | pubmed-author:ZweitJJ | lld:pubmed |
| pubmed-article:1618233 | pubmed:author | pubmed-author:PotterG AGA | lld:pubmed |
| pubmed-article:1618233 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1618233 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:1618233 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1618233 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1618233 | pubmed:pagination | 418-25 | lld:pubmed |
| pubmed-article:1618233 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1618233 | pubmed:meshHeading | pubmed-meshheading:1618233-... | lld:pubmed |
| pubmed-article:1618233 | pubmed:meshHeading | pubmed-meshheading:1618233-... | lld:pubmed |
| pubmed-article:1618233 | pubmed:meshHeading | pubmed-meshheading:1618233-... | lld:pubmed |
| pubmed-article:1618233 | pubmed:meshHeading | pubmed-meshheading:1618233-... | lld:pubmed |
| pubmed-article:1618233 | pubmed:meshHeading | pubmed-meshheading:1618233-... | lld:pubmed |
| pubmed-article:1618233 | pubmed:meshHeading | pubmed-meshheading:1618233-... | lld:pubmed |
| pubmed-article:1618233 | pubmed:meshHeading | pubmed-meshheading:1618233-... | lld:pubmed |
| pubmed-article:1618233 | pubmed:meshHeading | pubmed-meshheading:1618233-... | lld:pubmed |
| pubmed-article:1618233 | pubmed:meshHeading | pubmed-meshheading:1618233-... | lld:pubmed |
| pubmed-article:1618233 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1618233 | pubmed:articleTitle | Development of a high performance zinc-62/copper-62 radionuclide generator for positron emission tomography. | lld:pubmed |
| pubmed-article:1618233 | pubmed:affiliation | Joint Department of Physics, Royal Marsden Hospital, Sutton, Surrey, UK. | lld:pubmed |
| pubmed-article:1618233 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1618233 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1618233 | lld:pubmed |
