| pubmed-article:16179371 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16179371 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:16179371 | lifeskim:mentions | umls-concept:C0033325 | lld:lifeskim |
| pubmed-article:16179371 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:16179371 | lifeskim:mentions | umls-concept:C0005773 | lld:lifeskim |
| pubmed-article:16179371 | lifeskim:mentions | umls-concept:C0002874 | lld:lifeskim |
| pubmed-article:16179371 | lifeskim:mentions | umls-concept:C0021079 | lld:lifeskim |
| pubmed-article:16179371 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:16179371 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:16179371 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:16179371 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:16179371 | lifeskim:mentions | umls-concept:C0681842 | lld:lifeskim |
| pubmed-article:16179371 | lifeskim:mentions | umls-concept:C0205165 | lld:lifeskim |
| pubmed-article:16179371 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16179371 | pubmed:dateCreated | 2006-2-7 | lld:pubmed |
| pubmed-article:16179371 | pubmed:abstractText | We investigated the clinical significance of a minor population of paroxysmal nocturnal hemoglobinuria (PNH)-type blood cells in patients with acquired aplastic anemia (AA). We quantified CD55-CD59- granulocytes and red blood cells (RBCs) in peripheral blood from 122 patients with recently diagnosed AA and correlated numbers of PNH-type cells and responses to immunosuppressive therapy (IST). Flow cytometry detected 0.005% to 23.1% of GPI-AP- cells in 68% of patients with AA. Sixty-eight of 83 (91%) patients with an increased proportion of PNH-type cells (PNH+) responded to antithymocyte globulin (ATG) + cyclosporin (CsA) therapy, whereas 18 of 39 (48%) without such an increase (PNH-) responded. Failure-free survival rates were significantly higher (64%) among patients with PNH+ than patients with PNH- (12%) at 5 years, although overall survival rates were comparable between the groups. Numbers of PNH-type and normal-type cells increased in parallel among most patients with PNH+ who responded to IST, suggesting that these cells are equally sensitive to immune attack. These results indicate that a minor population of PNH-type cells represents a reliable marker of a positive IST response and a favorable prognosis among patients with AA. Furthermore, immune attack against hematopoietic stem cells that allows PNH clonal expansion might occur only at the onset of AA. | lld:pubmed |
| pubmed-article:16179371 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16179371 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16179371 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16179371 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16179371 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16179371 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16179371 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16179371 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:16179371 | pubmed:author | pubmed-author:MizoguchiHide... | lld:pubmed |
| pubmed-article:16179371 | pubmed:author | pubmed-author:NakaoShinjiS | lld:pubmed |
| pubmed-article:16179371 | pubmed:author | pubmed-author:TakamiAkiyosh... | lld:pubmed |
| pubmed-article:16179371 | pubmed:author | pubmed-author:ChuhjoTatsuya... | lld:pubmed |
| pubmed-article:16179371 | pubmed:author | pubmed-author:OmineMitsuhir... | lld:pubmed |
| pubmed-article:16179371 | pubmed:author | pubmed-author:TeramuraMasan... | lld:pubmed |
| pubmed-article:16179371 | pubmed:author | pubmed-author:SugimoriChiha... | lld:pubmed |
| pubmed-article:16179371 | pubmed:author | pubmed-author:FengXingminX | lld:pubmed |
| pubmed-article:16179371 | pubmed:author | pubmed-author:YamazakiHiroh... | lld:pubmed |
| pubmed-article:16179371 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16179371 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16179371 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:16179371 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16179371 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16179371 | pubmed:pagination | 1308-14 | lld:pubmed |
| pubmed-article:16179371 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16179371 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16179371 | pubmed:articleTitle | Minor population of CD55-CD59- blood cells predicts response to immunosuppressive therapy and prognosis in patients with aplastic anemia. | lld:pubmed |
| pubmed-article:16179371 | pubmed:affiliation | Cellular Transplantation Biology, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8641, Japan. | lld:pubmed |
| pubmed-article:16179371 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16179371 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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