| pubmed-article:16170365 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16170365 | lifeskim:mentions | umls-concept:C0025202 | lld:lifeskim |
| pubmed-article:16170365 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16170365 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:16170365 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16170365 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16170365 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16170365 | pubmed:dateCreated | 2006-1-6 | lld:pubmed |
| pubmed-article:16170365 | pubmed:abstractText | The human gene Hugl-1 (Llgl/Lgl1) has significant homology to the Drosophila tumor suppressor gene lethal(2)giant larvae (lgl). The lgl gene codes for a cortical cytoskeleton protein, Lgl, that is involved in maintaining cell polarity and epithelial integrity. We speculate that Hugl-1 might play a role in epithelial-mesenchymal transition (EMT) and that loss of Hugl-1 expression plays a role in the development or progression of malignant melanoma. Thus, we evaluated melanoma cell lines and tissue samples of malignant melanoma for loss of Hugl-1 transcription. We found that Hugl-1 was downregulated or lost in all cell lines and in most of the tumor samples analysed, and that these losses were associated with advanced stage of the disease. Reduced Hugl-1 expression occurred as early as in primary tumors detected by both immunohistochemical and reverse transcription-polymerase chain reaction (RT-PCR) analysis. Functional assays with stable Hugl-1-transfected cell lines revealed that Hugl-1 expression increased cell adhesion and decreased cell migration. Further, downregulation of MMP2 and MMP14 (MT1-MMP) and re-expression of E-cadherin was found in the Hugl-1-expressing cell clones supporting a role of Hugl-1 in EMT. Our studies thus indicate that loss of Hugl-1 expression contributes to melanoma progression. | lld:pubmed |
| pubmed-article:16170365 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16170365 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16170365 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16170365 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16170365 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16170365 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:16170365 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:16170365 | pubmed:author | pubmed-author:StrandSS | lld:pubmed |
| pubmed-article:16170365 | pubmed:author | pubmed-author:HoferPP | lld:pubmed |
| pubmed-article:16170365 | pubmed:author | pubmed-author:StrandDD | lld:pubmed |
| pubmed-article:16170365 | pubmed:author | pubmed-author:WallnerSS | lld:pubmed |
| pubmed-article:16170365 | pubmed:author | pubmed-author:BatailleFF | lld:pubmed |
| pubmed-article:16170365 | pubmed:author | pubmed-author:BosserhoffA... | lld:pubmed |
| pubmed-article:16170365 | pubmed:author | pubmed-author:SchimanskiC... | lld:pubmed |
| pubmed-article:16170365 | pubmed:author | pubmed-author:KuphalSS | lld:pubmed |
| pubmed-article:16170365 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16170365 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:16170365 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:16170365 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16170365 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16170365 | pubmed:pagination | 103-10 | lld:pubmed |
| pubmed-article:16170365 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16170365 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16170365 | pubmed:articleTitle | Expression of Hugl-1 is strongly reduced in malignant melanoma. | lld:pubmed |
| pubmed-article:16170365 | pubmed:affiliation | Institute of Pathology, University Regensburg, Regensburg, Germany. | lld:pubmed |
| pubmed-article:16170365 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16170365 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3996 | entrezgene:pubmed | pubmed-article:16170365 | lld:entrezgene |
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