| pubmed-article:16157683 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16157683 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:16157683 | lifeskim:mentions | umls-concept:C0001699 | lld:lifeskim |
| pubmed-article:16157683 | lifeskim:mentions | umls-concept:C0123759 | lld:lifeskim |
| pubmed-article:16157683 | lifeskim:mentions | umls-concept:C0963088 | lld:lifeskim |
| pubmed-article:16157683 | lifeskim:mentions | umls-concept:C0520990 | lld:lifeskim |
| pubmed-article:16157683 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16157683 | pubmed:dateCreated | 2005-9-20 | lld:pubmed |
| pubmed-article:16157683 | pubmed:abstractText | Interleukin (IL)-23 is a heterodimeric cytokine that shares the identical p40 subunit as IL-12 but exhibits a unique p19 subunit similar to IL-12 p35. IL-12/23 p40, interferon gamma (IFN-gamma), and IL-17 are critical for host defense against Klebsiella pneumoniae. In vitro, K. pneumoniae-pulsed dendritic cell culture supernatants elicit T cell IL-17 production in a IL-23-dependent manner. However, the importance of IL-23 during in vivo pulmonary challenge is unknown. We show that IL-12/23 p40-deficient mice are exquisitely sensitive to intrapulmonary K. pneumoniae inoculation and that IL-23 p19-/-, IL-17R-/-, and IL-12 p35-/- mice also show increased susceptibility to infection. p40-/- mice fail to generate pulmonary IFN-gamma, IL-17, or IL-17F responses to infection, whereas p35-/- mice show normal IL-17 and IL-17F induction but reduced IFN-gamma. Lung IL-17 and IL-17F production in p19-/- mice was dramatically reduced, and this strain showed substantial mortality from a sublethal dose of bacteria (10(3) CFU), despite normal IFN-gamma induction. Administration of IL-17 restored bacterial control in p19-/- mice and to a lesser degree in p40-/- mice, suggesting an additional host defense requirement for IFN-gamma in this strain. Together, these data demonstrate independent requirements for IL-12 and IL-23 in pulmonary host defense against K. pneumoniae, the former of which is required for IFN-gamma expression and the latter of which is required for IL-17 production. | lld:pubmed |
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| pubmed-article:16157683 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16157683 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16157683 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16157683 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16157683 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16157683 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:16157683 | pubmed:author | pubmed-author:KollsJay KJK | lld:pubmed |
| pubmed-article:16157683 | pubmed:author | pubmed-author:BagbyGregory... | lld:pubmed |
| pubmed-article:16157683 | pubmed:author | pubmed-author:NelsonSteveS | lld:pubmed |
| pubmed-article:16157683 | pubmed:author | pubmed-author:GhilardiNicoN | lld:pubmed |
| pubmed-article:16157683 | pubmed:author | pubmed-author:ShellitoJudd... | lld:pubmed |
| pubmed-article:16157683 | pubmed:author | pubmed-author:HappelKyle... | lld:pubmed |
| pubmed-article:16157683 | pubmed:author | pubmed-author:QuintonLee... | lld:pubmed |
| pubmed-article:16157683 | pubmed:author | pubmed-author:ZhengMingquan... | lld:pubmed |
| pubmed-article:16157683 | pubmed:author | pubmed-author:OddenAnthony... | lld:pubmed |
| pubmed-article:16157683 | pubmed:author | pubmed-author:DubinPatricia... | lld:pubmed |
| pubmed-article:16157683 | pubmed:author | pubmed-author:LockhartChris... | lld:pubmed |
| pubmed-article:16157683 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16157683 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:16157683 | pubmed:volume | 202 | lld:pubmed |
| pubmed-article:16157683 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16157683 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16157683 | pubmed:pagination | 761-9 | lld:pubmed |
| pubmed-article:16157683 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16157683 | pubmed:meshHeading | pubmed-meshheading:16157683... | lld:pubmed |
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