Linked Life Data

16154598

Source:http://linkedlifedata.com/resource/pubmed/id/16154598

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:16154598rdf:typepubmed:Citationlld:pubmed
pubmed-article:16154598lifeskim:mentionsumls-concept:C2349001lld:lifeskim
pubmed-article:16154598lifeskim:mentionsumls-concept:C0681850lld:lifeskim
pubmed-article:16154598lifeskim:mentionsumls-concept:C1706203lld:lifeskim
pubmed-article:16154598lifeskim:mentionsumls-concept:C2697811lld:lifeskim
pubmed-article:16154598lifeskim:mentionsumls-concept:C0027950lld:lifeskim
pubmed-article:16154598lifeskim:mentionsumls-concept:C0040135lld:lifeskim
pubmed-article:16154598lifeskim:mentionsumls-concept:C0040165lld:lifeskim
pubmed-article:16154598lifeskim:mentionsumls-concept:C0282636lld:lifeskim
pubmed-article:16154598lifeskim:mentionsumls-concept:C0920552lld:lifeskim
pubmed-article:16154598lifeskim:mentionsumls-concept:C1155915lld:lifeskim
pubmed-article:16154598lifeskim:mentionsumls-concept:C1550501lld:lifeskim
pubmed-article:16154598lifeskim:mentionsumls-concept:C0279033lld:lifeskim
pubmed-article:16154598lifeskim:mentionsumls-concept:C0205210lld:lifeskim
pubmed-article:16154598lifeskim:mentionsumls-concept:C0332120lld:lifeskim
pubmed-article:16154598pubmed:issue10lld:pubmed
pubmed-article:16154598pubmed:dateCreated2006-1-30lld:pubmed
pubmed-article:16154598pubmed:abstractTextMigration and superoxide anion (O2-) generation were studied in polymorphonuclear leukocytes (PMNs) from 14 athyreotic patients, previously treated by total thyroidectomy and radioiodine therapy for differentiated thyroid carcinoma, and from age- and sex-matched euthyroid healthy controls. Patients were studied twice: in hypothyroidism (visit 1) and after TSH-suppressive L-T4 replacement therapy (visit 2). Random migration and N-formyl-Met-Leu-Phe (fMLP) 0.1-microM induced chemotaxis were similar in cells from patients at both visit 1 and visit 2 and from healthy controls. On the contrary, resting O2- generation in cells from patients was significantly lower than control values, both at visit 1 and 2. At visit 1, fMLP 0.1 muM-induced O2- generation was significantly lower than control values, while phorbol-myristate acetate (PMA) 100-ng/ml induced O2- generation was similar in cells from patients and from controls. At visit 2 both responses increased, resulting in fMLP-induced O2- generation superimposable to control values and PMA-induced O2- generation significantly higher with respect to both visit 1 and cells from controls. In vitro exposure of PMNs from healthy subjects to L-T4 did not affect O2- generation in resting cells, and significantly increased that induced by fMLP or PMA only at high, supra-physiological concentrations. Neither TSH nor T3 had significant effects at any of the concentrations tested. The present results document the existence of a correlation between thyroid status and oxidative metabolism of human PMNs, which is however unlikely to depend upon a direct action of thyroid hormones on these cells.lld:pubmed
pubmed-article:16154598pubmed:languageenglld:pubmed
pubmed-article:16154598pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16154598pubmed:citationSubsetIMlld:pubmed
pubmed-article:16154598pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16154598pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16154598pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16154598pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16154598pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16154598pubmed:statusMEDLINElld:pubmed
pubmed-article:16154598pubmed:monthFeblld:pubmed
pubmed-article:16154598pubmed:issn0024-3205lld:pubmed
pubmed-article:16154598pubmed:authorpubmed-author:KlersyCatheri...lld:pubmed
pubmed-article:16154598pubmed:authorpubmed-author:BartalenaLuig...lld:pubmed
pubmed-article:16154598pubmed:authorpubmed-author:VencoAchilleAlld:pubmed
pubmed-article:16154598pubmed:authorpubmed-author:GuastiLuigina...lld:pubmed
pubmed-article:16154598pubmed:authorpubmed-author:SimoniCinziaClld:pubmed
pubmed-article:16154598pubmed:authorpubmed-author:CosentinoMarc...lld:pubmed
pubmed-article:16154598pubmed:authorpubmed-author:MarinoFrancaFlld:pubmed
pubmed-article:16154598pubmed:authorpubmed-author:LecchiniSergi...lld:pubmed
pubmed-article:16154598pubmed:authorpubmed-author:PiantanidaEli...lld:pubmed
pubmed-article:16154598pubmed:authorpubmed-author:CimpanelliMar...lld:pubmed
pubmed-article:16154598pubmed:authorpubmed-author:De...lld:pubmed
pubmed-article:16154598pubmed:issnTypePrintlld:pubmed
pubmed-article:16154598pubmed:day2lld:pubmed
pubmed-article:16154598pubmed:volume78lld:pubmed
pubmed-article:16154598pubmed:ownerNLMlld:pubmed
pubmed-article:16154598pubmed:authorsCompleteYlld:pubmed
pubmed-article:16154598pubmed:pagination1071-7lld:pubmed
pubmed-article:16154598pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:16154598pubmed:meshHeadingpubmed-meshheading:16154598...lld:pubmed
pubmed-article:16154598pubmed:meshHeadingpubmed-meshheading:16154598...lld:pubmed
pubmed-article:16154598pubmed:meshHeadingpubmed-meshheading:16154598...lld:pubmed
pubmed-article:16154598pubmed:meshHeadingpubmed-meshheading:16154598...lld:pubmed
pubmed-article:16154598pubmed:meshHeadingpubmed-meshheading:16154598...lld:pubmed
pubmed-article:16154598pubmed:meshHeadingpubmed-meshheading:16154598...lld:pubmed
pubmed-article:16154598pubmed:meshHeadingpubmed-meshheading:16154598...lld:pubmed
pubmed-article:16154598pubmed:meshHeadingpubmed-meshheading:16154598...lld:pubmed
pubmed-article:16154598pubmed:meshHeadingpubmed-meshheading:16154598...lld:pubmed
pubmed-article:16154598pubmed:meshHeadingpubmed-meshheading:16154598...lld:pubmed
pubmed-article:16154598pubmed:meshHeadingpubmed-meshheading:16154598...lld:pubmed
pubmed-article:16154598pubmed:meshHeadingpubmed-meshheading:16154598...lld:pubmed
pubmed-article:16154598pubmed:meshHeadingpubmed-meshheading:16154598...lld:pubmed
pubmed-article:16154598pubmed:meshHeadingpubmed-meshheading:16154598...lld:pubmed
pubmed-article:16154598pubmed:meshHeadingpubmed-meshheading:16154598...lld:pubmed
pubmed-article:16154598pubmed:meshHeadingpubmed-meshheading:16154598...lld:pubmed
pubmed-article:16154598pubmed:meshHeadingpubmed-meshheading:16154598...lld:pubmed
pubmed-article:16154598pubmed:meshHeadingpubmed-meshheading:16154598...lld:pubmed
pubmed-article:16154598pubmed:year2006lld:pubmed
pubmed-article:16154598pubmed:articleTitleThyroid hormone regulation of cell migration and oxidative metabolism in polymorphonuclear leukocytes: clinical evidence in thyroidectomized subjects on thyroxine replacement therapy.lld:pubmed
pubmed-article:16154598pubmed:affiliationDepartment of Clinical Medicine, Section of Experimental and Clinical Pharmacology, University of Insubria, Via Ottorino Rossi n. 9, 21100 Varese VA, Italy.lld:pubmed
pubmed-article:16154598pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16154598pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16154598lld:pubmed