| pubmed-article:1614959 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1614959 | lifeskim:mentions | umls-concept:C0085104 | lld:lifeskim |
| pubmed-article:1614959 | lifeskim:mentions | umls-concept:C0085174 | lld:lifeskim |
| pubmed-article:1614959 | lifeskim:mentions | umls-concept:C0006935 | lld:lifeskim |
| pubmed-article:1614959 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1614959 | pubmed:dateCreated | 1992-7-24 | lld:pubmed |
| pubmed-article:1614959 | pubmed:abstractText | A bilayer floating dosage unit is proposed to achieve local delivery of misoprostol, a prostaglandin E1 analogue, at the gastric mucosa level. The system is a capsule consisting of a floating layer maintaining the dosage unit buoyant upon the gastric content and a drug layer formulated to act as a sustained-delivery system. The differential design of the two layers allows the optimization of both floating capability and drug release profile. The layers are both composed of a hydrophilic matrix based upon hydroxypropylmethyl cellulose (HPMC). Parameters influencing the release profiles are described. The use of a large capsule increases the gastric residence time (GRT), as it impedes passage through the pylorus opening. gamma-Scintigraphic studies were performed to visualize cohesion of the two layers in vivo and to determine GRT as a function of meal regimen. The average GRTs were 199 +/- 69 min after a single meal (breakfast) and 618 +/- 208 min after a succession of meals. | lld:pubmed |
| pubmed-article:1614959 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1614959 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1614959 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1614959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1614959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1614959 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1614959 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1614959 | pubmed:issn | 0724-8741 | lld:pubmed |
| pubmed-article:1614959 | pubmed:author | pubmed-author:OttAA | lld:pubmed |
| pubmed-article:1614959 | pubmed:author | pubmed-author:TimmermansJJ | lld:pubmed |
| pubmed-article:1614959 | pubmed:author | pubmed-author:FranzMM | lld:pubmed |
| pubmed-article:1614959 | pubmed:author | pubmed-author:MöesAA | lld:pubmed |
| pubmed-article:1614959 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1614959 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:1614959 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1614959 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1614959 | pubmed:pagination | 298-302 | lld:pubmed |
| pubmed-article:1614959 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:1614959 | pubmed:meshHeading | pubmed-meshheading:1614959-... | lld:pubmed |
| pubmed-article:1614959 | pubmed:meshHeading | pubmed-meshheading:1614959-... | lld:pubmed |
| pubmed-article:1614959 | pubmed:meshHeading | pubmed-meshheading:1614959-... | lld:pubmed |
| pubmed-article:1614959 | pubmed:meshHeading | pubmed-meshheading:1614959-... | lld:pubmed |
| pubmed-article:1614959 | pubmed:meshHeading | pubmed-meshheading:1614959-... | lld:pubmed |
| pubmed-article:1614959 | pubmed:meshHeading | pubmed-meshheading:1614959-... | lld:pubmed |
| pubmed-article:1614959 | pubmed:meshHeading | pubmed-meshheading:1614959-... | lld:pubmed |
| pubmed-article:1614959 | pubmed:meshHeading | pubmed-meshheading:1614959-... | lld:pubmed |
| pubmed-article:1614959 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1614959 | pubmed:articleTitle | The bilayer floating capsule: a stomach-directed drug delivery system for misoprostol. | lld:pubmed |
| pubmed-article:1614959 | pubmed:affiliation | Searle European Development Centre, Mont-Saint-Guibert, Belgium. | lld:pubmed |
| pubmed-article:1614959 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1614959 | lld:pubmed |
