| pubmed-article:16147989 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16147989 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16147989 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:16147989 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:16147989 | lifeskim:mentions | umls-concept:C0035687 | lld:lifeskim |
| pubmed-article:16147989 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:16147989 | lifeskim:mentions | umls-concept:C0086222 | lld:lifeskim |
| pubmed-article:16147989 | lifeskim:mentions | umls-concept:C1704711 | lld:lifeskim |
| pubmed-article:16147989 | lifeskim:mentions | umls-concept:C1705733 | lld:lifeskim |
| pubmed-article:16147989 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:16147989 | pubmed:dateCreated | 2005-9-8 | lld:pubmed |
| pubmed-article:16147989 | pubmed:abstractText | Exonic splicing enhancers (ESEs) are pre-mRNA cis-acting elements required for splice-site recognition. We previously developed a web-based program called ESEfinder that scores any sequence for the presence of ESE motifs recognized by the human SR proteins SF2/ASF, SRp40, SRp55 and SC35 (http://rulai.cshl.edu/tools/ESE/). Using ESEfinder, we have undertaken a large-scale analysis of ESE motif distribution in human protein-coding genes. Significantly higher frequencies of ESE motifs were observed in constitutive internal protein-coding exons, compared with both their flanking intronic regions and with pseudo exons. Statistical analysis of ESE motif frequency distributions revealed a complex relationship between splice-site strength and increased or decreased frequencies of particular SR protein motifs. Comparison of constitutively and alternatively spliced exons demonstrated slightly weaker splice-site scores, as well as significantly fewer ESE motifs, in the alternatively spliced group. Our results underline the importance of ESE-mediated SR protein function in the process of exon definition, in the context of both constitutive splicing and regulated alternative splicing. | lld:pubmed |
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| pubmed-article:16147989 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16147989 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16147989 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16147989 | pubmed:issn | 1362-4962 | lld:pubmed |
| pubmed-article:16147989 | pubmed:author | pubmed-author:SmithPhilip... | lld:pubmed |
| pubmed-article:16147989 | pubmed:author | pubmed-author:KrainerAdrian... | lld:pubmed |
| pubmed-article:16147989 | pubmed:author | pubmed-author:ZhangMichael... | lld:pubmed |
| pubmed-article:16147989 | pubmed:author | pubmed-author:WangJinhuaJ | lld:pubmed |
| pubmed-article:16147989 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16147989 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:16147989 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16147989 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16147989 | pubmed:pagination | 5053-62 | lld:pubmed |
| pubmed-article:16147989 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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