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pubmed-article:16146539pubmed:abstractTextData on 90 patients (55 adults and 35 children) with chronic idiopathic thrombocytopenic purpura (ITP) and a platelet count of <50 x 10(9)/L treated with dapsone at a dose of 1-2 mg/kg/d are presented. A response was observed in 57 (63.3%) patients. The average time for response was 3.5 months (range 1-9) and the average duration of treatment with dapsone was 10.4 months (range 4-14). Overall response rates of 65.7% and 61.8% were observed in children and adults respectively. Side effects requiring discontinuation of therapy were observed in three (2%) patients. These results demonstrate that dapsone is an effective, inexpensive and well-tolerated treatment for chronic ITP, in both children and adults and could be considered for patients who fail steroid therapy.lld:pubmed
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pubmed-article:16146539pubmed:articleTitleDapsone for chronic idiopathic thrombocytopenic purpura in children and adults--a report on 90 patients.lld:pubmed
pubmed-article:16146539pubmed:affiliationDepartment of Haematology, Christian Medical College, Vellore-632004, Tamil Nadu, India.lld:pubmed
pubmed-article:16146539pubmed:publicationTypeJournal Articlelld:pubmed