| pubmed-article:16143832 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16143832 | lifeskim:mentions | umls-concept:C0038172 | lld:lifeskim |
| pubmed-article:16143832 | lifeskim:mentions | umls-concept:C0017428 | lld:lifeskim |
| pubmed-article:16143832 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:16143832 | lifeskim:mentions | umls-concept:C0242646 | lld:lifeskim |
| pubmed-article:16143832 | lifeskim:mentions | umls-concept:C0032167 | lld:lifeskim |
| pubmed-article:16143832 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:16143832 | pubmed:dateCreated | 2005-12-2 | lld:pubmed |
| pubmed-article:16143832 | pubmed:abstractText | Staphylococci have two mechanisms for resistance to beta-lactam antibiotics. One is the production of beta-lactamases, enzymes that hydrolytically destroy beta-lactams. The other is the expression of penicillin-binding protein 2a (PBP 2a), which is not susceptible to inhibition by beta-lactam antibiotics. Strains of S. aureus exhibiting either beta-lactamase or PBP 2a-directed resistance (or both) have established a considerable ecological niche among human pathogens. The emergence and subsequent spread of bacterial strains designated as methicillin-resistant S. aureus (MRSA), from the 1960s to the present, has created clinical difficulties for nosocomial treatment on a global scale. The recent variants of MRSA that are resistant to glycopeptide antibiotics (such as vancomycin) have ushered in a new and disconcerting chapter in the evolution of this organism. | lld:pubmed |
| pubmed-article:16143832 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16143832 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16143832 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16143832 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16143832 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16143832 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16143832 | pubmed:issn | 1420-682X | lld:pubmed |
| pubmed-article:16143832 | pubmed:author | pubmed-author:FisherJ FJF | lld:pubmed |
| pubmed-article:16143832 | pubmed:author | pubmed-author:MobasherySS | lld:pubmed |
| pubmed-article:16143832 | pubmed:author | pubmed-author:FudaC C SCC | lld:pubmed |
| pubmed-article:16143832 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16143832 | pubmed:volume | 62 | lld:pubmed |
| pubmed-article:16143832 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16143832 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16143832 | pubmed:pagination | 2617-33 | lld:pubmed |
| pubmed-article:16143832 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16143832 | pubmed:meshHeading | pubmed-meshheading:16143832... | lld:pubmed |
| pubmed-article:16143832 | pubmed:meshHeading | pubmed-meshheading:16143832... | lld:pubmed |
| pubmed-article:16143832 | pubmed:meshHeading | pubmed-meshheading:16143832... | lld:pubmed |
| pubmed-article:16143832 | pubmed:meshHeading | pubmed-meshheading:16143832... | lld:pubmed |
| pubmed-article:16143832 | pubmed:meshHeading | pubmed-meshheading:16143832... | lld:pubmed |
| pubmed-article:16143832 | pubmed:meshHeading | pubmed-meshheading:16143832... | lld:pubmed |
| pubmed-article:16143832 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16143832 | pubmed:articleTitle | Beta-lactam resistance in Staphylococcus aureus: the adaptive resistance of a plastic genome. | lld:pubmed |
| pubmed-article:16143832 | pubmed:affiliation | Department of Chemistry and Biochemistry, University of Notre Dame, Indiana, 46556-5670, USA. | lld:pubmed |
| pubmed-article:16143832 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16143832 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:16143832 | pubmed:publicationType | Review | lld:pubmed |
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