Linked Life Data

16135511

Source:http://linkedlifedata.com/resource/pubmed/id/16135511

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pubmed-article:16135511pubmed:dateCreated2005-12-5lld:pubmed
pubmed-article:16135511pubmed:abstractTextKeyhole limpet hemocyanin (KLH) of the mollusc Megathura crenulata is known to serologically cross-react with Schistosoma mansoni glycoconjugates in a carbohydrate-dependent manner. To elucidate the structural basis for this cross-reactivity, KLH glycans were released from tryptic glycopeptides and fluorescently labeled. Cross-reacting glycans were identified using a polyclonal antiserum reacting with soluble S. mansoni egg antigens, isolated by a three-dimensional fractionation scheme and analyzed by different mass spectrometric techniques as well as linkage analysis and exoglycosidase treatment. The results revealed that cross-reacting species comprise approximately 4.5% of released glycans. They all represent novel types of N-glycans with a Fuc(alpha1-3)GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc motif, which is known to occur also in schistosomal glycoconjugates. The tetrasaccharide unit is attached to the 3-linked antenna of a trimannosyl core, which can be further decorated by galactosyl residues, a xylose residue in 2-position of the central mannose and/or a fucose at the innermost N-acetylglucosamine. This study provides for the first time detailed structural data on the KLH carbohydrate entities responsible for cross-reactivity with glycoconjugates from S. mansoni.lld:pubmed
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pubmed-article:16135511pubmed:authorpubmed-author:GeyerRudolfRlld:pubmed
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pubmed-article:16135511pubmed:pagination40731-48lld:pubmed
pubmed-article:16135511pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:16135511pubmed:year2005lld:pubmed
pubmed-article:16135511pubmed:articleTitleIdentification and characterization of keyhole limpet hemocyanin N-glycans mediating cross-reactivity with Schistosoma mansoni.lld:pubmed
pubmed-article:16135511pubmed:affiliationInstitute of Biochemistry, Faculty of Medicine, University of Giessen, Friedrichstrasse 24, D-35392 Giessen, Germany.lld:pubmed
pubmed-article:16135511pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16135511pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:16135511pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed