| pubmed-article:1613318 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1613318 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:1613318 | lifeskim:mentions | umls-concept:C0032140 | lld:lifeskim |
| pubmed-article:1613318 | lifeskim:mentions | umls-concept:C0040044 | lld:lifeskim |
| pubmed-article:1613318 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:1613318 | lifeskim:mentions | umls-concept:C2349209 | lld:lifeskim |
| pubmed-article:1613318 | lifeskim:mentions | umls-concept:C1549649 | lld:lifeskim |
| pubmed-article:1613318 | lifeskim:mentions | umls-concept:C0333668 | lld:lifeskim |
| pubmed-article:1613318 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1613318 | pubmed:dateCreated | 1992-7-28 | lld:pubmed |
| pubmed-article:1613318 | pubmed:abstractText | Thrombolytic therapy frequently induces a "lytic state" associated with a decrease in plasma plasminogen concentration that could limit therapeutic efficacy. We therefore investigated the influence of soluble plasminogen concentration on in vitro lysis of retracted whole-blood clots in plasma from normal subjects and from patients undergoing thrombolytic therapy. With recombinant tissue plasminogen activator (1000 ng/ml) or two-chain urokinase plasminogen activator (250 U/ml), minimal clot lysis occurred in normal plasma depleted of plasminogen by lysine Sepharose chromatography. Clot lysis induced by two-chain urokinase plasminogen activator increased progressively in normal plasma at initial plasminogen concentrations between 0.06 to 6 U/ml, whereas maximum lysis with recombinant tissue plasminogen activator occurred between 0.5 U/ml and 1 U/ml and was less at lower and higher concentrations of plasminogen. Incubation of whole-blood clots in normal plasma with recombinant tissue plasminogen activator resulted in little change in plasminogen concentration during 6 hours, with a constant rate of clot lysis. Incubation with two-chain urokinase plasminogen activator, however, caused a rapid decrease in plasminogen concentration and a corresponding decrease in lysis rate; lysis rate was restored after repletion with purified plasminogen. The effect of in vivo activator-induced plasminogen depletion on in vitro clot lysis rates was tested with plasma obtained from patients 90 to 120 minutes after they had received 30 mg of acylated plasminogen-streptokinase activator complex that showed depletion of plasminogen to 14% +/- 2%. These plasma samples produced only 4% +/- 1% in vitro clot lysis during 4 hours but lysis increased progressively after repletion with 1, 2, and 4 U/ml plasminogen.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:1613318 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1613318 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1613318 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1613318 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1613318 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1613318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1613318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1613318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1613318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1613318 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1613318 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:1613318 | pubmed:issn | 0022-2143 | lld:pubmed |
| pubmed-article:1613318 | pubmed:author | pubmed-author:MarderV JVJ | lld:pubmed |
| pubmed-article:1613318 | pubmed:author | pubmed-author:FrancisC WCW | lld:pubmed |
| pubmed-article:1613318 | pubmed:author | pubmed-author:OnundarsonP... | lld:pubmed |
| pubmed-article:1613318 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1613318 | pubmed:volume | 120 | lld:pubmed |
| pubmed-article:1613318 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1613318 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1613318 | pubmed:pagination | 120-8 | lld:pubmed |
| pubmed-article:1613318 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:1613318 | pubmed:meshHeading | pubmed-meshheading:1613318-... | lld:pubmed |
| pubmed-article:1613318 | pubmed:meshHeading | pubmed-meshheading:1613318-... | lld:pubmed |
| pubmed-article:1613318 | pubmed:meshHeading | pubmed-meshheading:1613318-... | lld:pubmed |
| pubmed-article:1613318 | pubmed:meshHeading | pubmed-meshheading:1613318-... | lld:pubmed |
| pubmed-article:1613318 | pubmed:meshHeading | pubmed-meshheading:1613318-... | lld:pubmed |
| pubmed-article:1613318 | pubmed:meshHeading | pubmed-meshheading:1613318-... | lld:pubmed |
| pubmed-article:1613318 | pubmed:meshHeading | pubmed-meshheading:1613318-... | lld:pubmed |
| pubmed-article:1613318 | pubmed:meshHeading | pubmed-meshheading:1613318-... | lld:pubmed |
| pubmed-article:1613318 | pubmed:meshHeading | pubmed-meshheading:1613318-... | lld:pubmed |
| pubmed-article:1613318 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1613318 | pubmed:articleTitle | Depletion of plasminogen in vitro or during thrombolytic therapy limits fibrinolytic potential. | lld:pubmed |
| pubmed-article:1613318 | pubmed:affiliation | Department of Medicine, University of Rochester School of Medicine and Dentistry, New York. | lld:pubmed |
| pubmed-article:1613318 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1613318 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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