| pubmed-article:16126996 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16126996 | lifeskim:mentions | umls-concept:C0004368 | lld:lifeskim |
| pubmed-article:16126996 | lifeskim:mentions | umls-concept:C0450442 | lld:lifeskim |
| pubmed-article:16126996 | pubmed:dateCreated | 2005-8-29 | lld:pubmed |
| pubmed-article:16126996 | pubmed:abstractText | Treatment of rheumatoid arthritis (RA) patients with anti-tumor necrosis factor-alpha (anti-TNF-alpha) biologic agents has been associated with a reduction in the levels of specific autoantibodies, such as rheumatoid factor (RF) and anticyclic citrullinated peptide (anti-CCP), and the induction of non- organ-specific autoantibodies (antinuclear antibodies [ANAs], anti-dsDNA, and antiphospholipid antibodies [aPLs]). The mechanisms by which the blockade of anti-TNF-alpha decreases the generation of specific autoantibodies, such as anti-CCP and RF, are not yet known. However, it has been shown that these agents can downregulate the production of several inflammatory cytokines and mediators and that these anti-inflammatory effects may account for reduced autoantibody generation, particularly in the synovial compartment. Infliximab treatment leads to the induction of ANAs in 63.8% of RA patients and 49.1% of Crohn's disease (CD) patients, and anti-dsDNA antibodies in 13% of RA patients and 21.5% of CD patients, respectively. The development of ANAs and anti-dsDNA antibodies has also been described after etanercept therapy in 11% and 15% of RA patients, respectively. In the controlled trials, increases in ANA and anti-dsDNA titers were observed in 5.3% and in 12.9% of adalimumab-treated RA patients. Only limited data on the induction of aPL antibodies during TNF-alpha blocking treatment are available. | lld:pubmed |
| pubmed-article:16126996 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16126996 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16126996 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16126996 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16126996 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16126996 | pubmed:issn | 0077-8923 | lld:pubmed |
| pubmed-article:16126996 | pubmed:author | pubmed-author:DoriaAndreaA | lld:pubmed |
| pubmed-article:16126996 | pubmed:author | pubmed-author:Sarzi-Puttini... | lld:pubmed |
| pubmed-article:16126996 | pubmed:author | pubmed-author:TurielMaurizi... | lld:pubmed |
| pubmed-article:16126996 | pubmed:author | pubmed-author:AtzeniFabiola... | lld:pubmed |
| pubmed-article:16126996 | pubmed:author | pubmed-author:MeroniPierlui... | lld:pubmed |
| pubmed-article:16126996 | pubmed:author | pubmed-author:CapsoniFranco... | lld:pubmed |
| pubmed-article:16126996 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16126996 | pubmed:volume | 1051 | lld:pubmed |
| pubmed-article:16126996 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16126996 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16126996 | pubmed:pagination | 559-69 | lld:pubmed |
| pubmed-article:16126996 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:16126996 | pubmed:meshHeading | pubmed-meshheading:16126996... | lld:pubmed |
| pubmed-article:16126996 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16126996 | pubmed:articleTitle | Autoimmunity and anti-TNF-alpha agents. | lld:pubmed |
| pubmed-article:16126996 | pubmed:affiliation | Rheumatology Unit, Department of Rheumatology, University Hospital L Sacco, Via GB Grassi 74, 20157 Milan, Italy. sarzi@tiscali.it | lld:pubmed |
| pubmed-article:16126996 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16126996 | pubmed:publicationType | Review | lld:pubmed |
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