Linked Life Data

16123346

Source:http://linkedlifedata.com/resource/pubmed/id/16123346

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:16123346rdf:typepubmed:Citationlld:pubmed
pubmed-article:16123346lifeskim:mentionsumls-concept:C0001675lld:lifeskim
pubmed-article:16123346lifeskim:mentionsumls-concept:C0035820lld:lifeskim
pubmed-article:16123346lifeskim:mentionsumls-concept:C0024501lld:lifeskim
pubmed-article:16123346lifeskim:mentionsumls-concept:C0030274lld:lifeskim
pubmed-article:16123346lifeskim:mentionsumls-concept:C0034963lld:lifeskim
pubmed-article:16123346lifeskim:mentionsumls-concept:C0040648lld:lifeskim
pubmed-article:16123346lifeskim:mentionsumls-concept:C0017262lld:lifeskim
pubmed-article:16123346lifeskim:mentionsumls-concept:C1427500lld:lifeskim
pubmed-article:16123346lifeskim:mentionsumls-concept:C1826562lld:lifeskim
pubmed-article:16123346lifeskim:mentionsumls-concept:C0598306lld:lifeskim
pubmed-article:16123346lifeskim:mentionsumls-concept:C1701901lld:lifeskim
pubmed-article:16123346lifeskim:mentionsumls-concept:C2911684lld:lifeskim
pubmed-article:16123346lifeskim:mentionsumls-concept:C0185117lld:lifeskim
pubmed-article:16123346pubmed:issue9lld:pubmed
pubmed-article:16123346pubmed:dateCreated2005-8-26lld:pubmed
pubmed-article:16123346pubmed:abstractTextThe homeodomain transcription factor Pdx1 is essential for pancreas development. To investigate the role of Pdx1 in the adult pancreas, we employed a mouse model in which transcription of Pdx1 could be reversibly repressed by administration of doxycycline. Repression of Pdx1 in adult mice impaired expression of insulin and glucagon, leading to diabetes within 14 days. Pdx1 repression was associated with increased cell proliferation predominantly in the exocrine pancreas and upregulation of genes implicated in pancreas regeneration. Following withdrawal of doxycycline and derepression of Pdx1, normoglycemia was restored within 28 days; during this period, Pdx1(+)/Ins(+) and Pdx(+)/Ins(-) cells were observed in association with the duct epithelia. These findings confirm that Pdx1 is required for beta-cell function in the adult pancreas and indicate that in the absence of Pdx1 expression, a regenerative program is initiated with the potential for Pdx1-dependent beta-cell neogenesis.lld:pubmed
pubmed-article:16123346pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16123346pubmed:languageenglld:pubmed
pubmed-article:16123346pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16123346pubmed:citationSubsetAIMlld:pubmed
pubmed-article:16123346pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16123346pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16123346pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16123346pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16123346pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16123346pubmed:statusMEDLINElld:pubmed
pubmed-article:16123346pubmed:monthSeplld:pubmed
pubmed-article:16123346pubmed:issn0012-1797lld:pubmed
pubmed-article:16123346pubmed:authorpubmed-author:HarrisonLeona...lld:pubmed
pubmed-article:16123346pubmed:authorpubmed-author:HollandAndrew...lld:pubmed
pubmed-article:16123346pubmed:authorpubmed-author:NaselliGaetan...lld:pubmed
pubmed-article:16123346pubmed:authorpubmed-author:GóñezL...lld:pubmed
pubmed-article:16123346pubmed:authorpubmed-author:MacdonaldRaym...lld:pubmed
pubmed-article:16123346pubmed:issnTypePrintlld:pubmed
pubmed-article:16123346pubmed:volume54lld:pubmed
pubmed-article:16123346pubmed:ownerNLMlld:pubmed
pubmed-article:16123346pubmed:authorsCompleteYlld:pubmed
pubmed-article:16123346pubmed:pagination2586-95lld:pubmed
pubmed-article:16123346pubmed:dateRevised2011-11-17lld:pubmed
pubmed-article:16123346pubmed:meshHeadingpubmed-meshheading:16123346...lld:pubmed
pubmed-article:16123346pubmed:meshHeadingpubmed-meshheading:16123346...lld:pubmed
pubmed-article:16123346pubmed:meshHeadingpubmed-meshheading:16123346...lld:pubmed
pubmed-article:16123346pubmed:meshHeadingpubmed-meshheading:16123346...lld:pubmed
pubmed-article:16123346pubmed:meshHeadingpubmed-meshheading:16123346...lld:pubmed
pubmed-article:16123346pubmed:meshHeadingpubmed-meshheading:16123346...lld:pubmed
pubmed-article:16123346pubmed:meshHeadingpubmed-meshheading:16123346...lld:pubmed
pubmed-article:16123346pubmed:meshHeadingpubmed-meshheading:16123346...lld:pubmed
pubmed-article:16123346pubmed:meshHeadingpubmed-meshheading:16123346...lld:pubmed
pubmed-article:16123346pubmed:meshHeadingpubmed-meshheading:16123346...lld:pubmed
pubmed-article:16123346pubmed:meshHeadingpubmed-meshheading:16123346...lld:pubmed
pubmed-article:16123346pubmed:meshHeadingpubmed-meshheading:16123346...lld:pubmed
pubmed-article:16123346pubmed:meshHeadingpubmed-meshheading:16123346...lld:pubmed
pubmed-article:16123346pubmed:year2005lld:pubmed
pubmed-article:16123346pubmed:articleTitleConditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas.lld:pubmed
pubmed-article:16123346pubmed:affiliationAutoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia.lld:pubmed
pubmed-article:16123346pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16123346pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:16123346pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:16123346pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
entrez-gene:18609entrezgene:pubmedpubmed-article:16123346lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16123346lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16123346lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16123346lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16123346lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16123346lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16123346lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16123346lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16123346lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16123346lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16123346lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16123346lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16123346lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16123346lld:pubmed