| pubmed-article:16115959 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16115959 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:16115959 | lifeskim:mentions | umls-concept:C0021701 | lld:lifeskim |
| pubmed-article:16115959 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:16115959 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:16115959 | lifeskim:mentions | umls-concept:C1709439 | lld:lifeskim |
| pubmed-article:16115959 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:16115959 | lifeskim:mentions | umls-concept:C1704735 | lld:lifeskim |
| pubmed-article:16115959 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:16115959 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:16115959 | pubmed:dateCreated | 2005-8-30 | lld:pubmed |
| pubmed-article:16115959 | pubmed:abstractText | Outside-in integrin alphaIIbbeta3 signaling is required for normal platelet thrombus formation and is triggered by c-Src activation through an unknown mechanism. In this study, we demonstrate an essential role for protein-tyrosine phosphatase (PTP)-1B in this process. In resting platelets, c-Src forms a complex with alphaIIbbeta3 and Csk, which phosphorylates c-Src tyrosine 529 to maintain c-Src autoinhibition. Fibrinogen binding to alphaIIbbeta3 triggers PTP-1B recruitment to the alphaIIbbeta3-c-Src-Csk complex in a manner that is dependent on c-Src and specific tyrosine (tyrosine 152 and 153) and proline (proline 309 and 310) residues in PTP-1B. Studies of PTP-1B-deficient mouse platelets indicate that PTP-1B is required for fibrinogen-dependent Csk dissociation from alphaIIbbeta3, dephosphorylation of c-Src tyrosine 529, and c-Src activation. Furthermore, PTP-1B-deficient platelets are defective in outside-in alphaIIbbeta3 signaling in vitro as manifested by poor spreading on fibrinogen and decreased clot retraction, and they exhibit ineffective Ca2+ signaling and thrombus formation in vivo. Thus, PTP-1B is an essential positive regulator of the initiation of outside-in alphaIIbbeta3 signaling in platelets. | lld:pubmed |
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| pubmed-article:16115959 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16115959 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16115959 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16115959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16115959 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16115959 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16115959 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:16115959 | pubmed:author | pubmed-author:ShattilSanfor... | lld:pubmed |
| pubmed-article:16115959 | pubmed:author | pubmed-author:Kasirer-Fried... | lld:pubmed |
| pubmed-article:16115959 | pubmed:author | pubmed-author:NeelBenjamin... | lld:pubmed |
| pubmed-article:16115959 | pubmed:author | pubmed-author:HajFawazF | lld:pubmed |
| pubmed-article:16115959 | pubmed:author | pubmed-author:FurieBarbara... | lld:pubmed |
| pubmed-article:16115959 | pubmed:author | pubmed-author:FurieBruceB | lld:pubmed |
