| pubmed-article:16105879 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16105879 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:16105879 | lifeskim:mentions | umls-concept:C1171346 | lld:lifeskim |
| pubmed-article:16105879 | lifeskim:mentions | umls-concept:C0007709 | lld:lifeskim |
| pubmed-article:16105879 | lifeskim:mentions | umls-concept:C1156185 | lld:lifeskim |
| pubmed-article:16105879 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:16105879 | pubmed:issue | Pt 17 | lld:pubmed |
| pubmed-article:16105879 | pubmed:dateCreated | 2005-8-30 | lld:pubmed |
| pubmed-article:16105879 | pubmed:abstractText | Nuclear organisation is thought to be important in regulating gene expression. Here we investigate whether human embryonic stem cells (hES) have a particular nuclear organisation, which could be important for maintaining their pluripotent state. We found that whereas the nuclei of hES cells have a general gene-density-related radial organisation of chromosomes, as is seen in differentiated cells, there are also distinctive localisations for chromosome regions and gene loci with a role in pluripotency. Chromosome 12p, a region of the human genome that contains clustered pluripotency genes including NANOG, has a more central nuclear localisation in ES cells than in differentiated cells. On chromosome 6p we find no overall change in nuclear chromosome position, but instead we detect a relocalisation of the OCT4 locus, to a position outside its chromosome territory. There is also a smaller proportion of centromeres located close to the nuclear periphery in hES cells compared to differentiated cells. We conclude that hES cell nuclei have a distinct nuclear architecture, especially at loci involved in maintaining pluripotency. Understanding this level of hES cell biology provides a framework within which other large-scale chromatin changes that may accompany differentiation can be considered. | lld:pubmed |
| pubmed-article:16105879 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16105879 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16105879 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16105879 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16105879 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16105879 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16105879 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16105879 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16105879 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16105879 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16105879 | pubmed:issn | 0021-9533 | lld:pubmed |
| pubmed-article:16105879 | pubmed:author | pubmed-author:YaiD IDI | lld:pubmed |
| pubmed-article:16105879 | pubmed:author | pubmed-author:ClarkA JohnAJ | lld:pubmed |
| pubmed-article:16105879 | pubmed:author | pubmed-author:BickmoreWendy... | lld:pubmed |
| pubmed-article:16105879 | pubmed:author | pubmed-author:WiblinAnne... | lld:pubmed |
| pubmed-article:16105879 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16105879 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16105879 | pubmed:volume | 118 | lld:pubmed |
| pubmed-article:16105879 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16105879 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16105879 | pubmed:pagination | 3861-8 | lld:pubmed |
| pubmed-article:16105879 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16105879 | pubmed:meshHeading | pubmed-meshheading:16105879... | lld:pubmed |
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| pubmed-article:16105879 | pubmed:meshHeading | pubmed-meshheading:16105879... | lld:pubmed |
| pubmed-article:16105879 | pubmed:meshHeading | pubmed-meshheading:16105879... | lld:pubmed |
| pubmed-article:16105879 | pubmed:meshHeading | pubmed-meshheading:16105879... | lld:pubmed |
| pubmed-article:16105879 | pubmed:meshHeading | pubmed-meshheading:16105879... | lld:pubmed |
| pubmed-article:16105879 | pubmed:meshHeading | pubmed-meshheading:16105879... | lld:pubmed |
| pubmed-article:16105879 | pubmed:meshHeading | pubmed-meshheading:16105879... | lld:pubmed |
| pubmed-article:16105879 | pubmed:meshHeading | pubmed-meshheading:16105879... | lld:pubmed |
| pubmed-article:16105879 | pubmed:meshHeading | pubmed-meshheading:16105879... | lld:pubmed |
| pubmed-article:16105879 | pubmed:meshHeading | pubmed-meshheading:16105879... | lld:pubmed |
| pubmed-article:16105879 | pubmed:meshHeading | pubmed-meshheading:16105879... | lld:pubmed |
| pubmed-article:16105879 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16105879 | pubmed:articleTitle | Distinctive nuclear organisation of centromeres and regions involved in pluripotency in human embryonic stem cells. | lld:pubmed |
| pubmed-article:16105879 | pubmed:affiliation | MRC Human Genetics Unit, Crewe Road, Edinburgh, EH4 2XU, UK. | lld:pubmed |
| pubmed-article:16105879 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16105879 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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