| pubmed-article:16098465 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16098465 | lifeskim:mentions | umls-concept:C0079427 | lld:lifeskim |
| pubmed-article:16098465 | lifeskim:mentions | umls-concept:C0334579 | lld:lifeskim |
| pubmed-article:16098465 | lifeskim:mentions | umls-concept:C0080055 | lld:lifeskim |
| pubmed-article:16098465 | lifeskim:mentions | umls-concept:C0085113 | lld:lifeskim |
| pubmed-article:16098465 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16098465 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:16098465 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16098465 | pubmed:dateCreated | 2005-8-15 | lld:pubmed |
| pubmed-article:16098465 | pubmed:abstractText | Malignant astrocytoma, the most prevalent primary brain tumor, is resistant to all known therapies and frequently harbors mutations that inactivate p53 and activate Ras signaling. We have generated mouse strains that lack p53 and harbor a conditional allele of the NF1 tumor suppressor that negatively regulates Ras signaling. The mice develop malignant astrocytomas with complete penetrance. The majority of tumors display characteristics of glioblastoma multiforme with concomitant alteration of signaling pathways previously described in the human counterparts of this neoplasm. We find that the sequence of tumor suppressor inactivation influences tumorigenicity and that earliest evidence of tumor formation localizes to regions of the brain that contain a multipotent stem cell population capable of in vivo differentiation into neurons and glia. | lld:pubmed |
| pubmed-article:16098465 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16098465 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16098465 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16098465 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16098465 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16098465 | pubmed:issn | 1535-6108 | lld:pubmed |
| pubmed-article:16098465 | pubmed:author | pubmed-author:JosKK | lld:pubmed |
| pubmed-article:16098465 | pubmed:author | pubmed-author:MessingAlbeeA | lld:pubmed |
| pubmed-article:16098465 | pubmed:author | pubmed-author:ZhuYuanY | lld:pubmed |
| pubmed-article:16098465 | pubmed:author | pubmed-author:BurnsDennis... | lld:pubmed |
| pubmed-article:16098465 | pubmed:author | pubmed-author:ParadaLuis... | lld:pubmed |
| pubmed-article:16098465 | pubmed:author | pubmed-author:ZhaoDawenD | lld:pubmed |
| pubmed-article:16098465 | pubmed:author | pubmed-author:MasonRalph... | lld:pubmed |
| pubmed-article:16098465 | pubmed:author | pubmed-author:GuignardFrant... | lld:pubmed |
| pubmed-article:16098465 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16098465 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:16098465 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16098465 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16098465 | pubmed:pagination | 119-30 | lld:pubmed |
| pubmed-article:16098465 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:16098465 | pubmed:meshHeading | pubmed-meshheading:16098465... | lld:pubmed |
| pubmed-article:16098465 | pubmed:meshHeading | pubmed-meshheading:16098465... | lld:pubmed |
| pubmed-article:16098465 | pubmed:meshHeading | pubmed-meshheading:16098465... | lld:pubmed |
| pubmed-article:16098465 | pubmed:meshHeading | pubmed-meshheading:16098465... | lld:pubmed |
