| pubmed-article:16095561 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16095561 | lifeskim:mentions | umls-concept:C1309483 | lld:lifeskim |
| pubmed-article:16095561 | lifeskim:mentions | umls-concept:C0040711 | lld:lifeskim |
| pubmed-article:16095561 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:16095561 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:16095561 | lifeskim:mentions | umls-concept:C1333218 | lld:lifeskim |
| pubmed-article:16095561 | lifeskim:mentions | umls-concept:C0013682 | lld:lifeskim |
| pubmed-article:16095561 | lifeskim:mentions | umls-concept:C0205231 | lld:lifeskim |
| pubmed-article:16095561 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16095561 | pubmed:dateCreated | 2005-8-23 | lld:pubmed |
| pubmed-article:16095561 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16095561 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16095561 | pubmed:abstractText | The Dicer enzyme is a key component of the RNA interference pathway and also responsible for the processing of micro RNAs, non-coding RNA molecules which regulate the activity of mRNAs by antisense base pairing. Little is known about the structure and regulation of human Dicer mRNA. A comprehensive characterization of Dicer 5'-untranslated region (5'-UTR) RNA structure revealed important diversity within human Dicer mRNA transcripts. Three exon 1 variants were defined, some of which exhibited very restricted patterns of tissue distribution. A number of alternatively spliced 5'-leader exons were also noted, revealing the potential for complex post-transcriptional regulation. Surprisingly, this diversity all occurred within the 5'-UTR of Dicer mRNAs and did not affect the coding region. The Dicer mRNA 5'-UTR variants had profound effects on translational efficiency both in vitro and in transiently transfected cells. A number of major Dicer RNA species are inefficient substrates for the translational machinery. | lld:pubmed |
| pubmed-article:16095561 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16095561 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16095561 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16095561 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16095561 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16095561 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16095561 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16095561 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16095561 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:16095561 | pubmed:author | pubmed-author:NewtonDerek... | lld:pubmed |
| pubmed-article:16095561 | pubmed:author | pubmed-author:MarsdenPhilip... | lld:pubmed |
| pubmed-article:16095561 | pubmed:author | pubmed-author:BevanSian CSC | lld:pubmed |
| pubmed-article:16095561 | pubmed:author | pubmed-author:SinghSundeepS | lld:pubmed |
| pubmed-article:16095561 | pubmed:author | pubmed-author:PatilKedarK | lld:pubmed |
| pubmed-article:16095561 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16095561 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:16095561 | pubmed:volume | 335 | lld:pubmed |
| pubmed-article:16095561 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16095561 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16095561 | pubmed:pagination | 643-50 | lld:pubmed |
| pubmed-article:16095561 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16095561 | pubmed:meshHeading | pubmed-meshheading:16095561... | lld:pubmed |
| pubmed-article:16095561 | pubmed:meshHeading | pubmed-meshheading:16095561... | lld:pubmed |
| pubmed-article:16095561 | pubmed:meshHeading | pubmed-meshheading:16095561... | lld:pubmed |
| pubmed-article:16095561 | pubmed:meshHeading | pubmed-meshheading:16095561... | lld:pubmed |
| pubmed-article:16095561 | pubmed:meshHeading | pubmed-meshheading:16095561... | lld:pubmed |
| pubmed-article:16095561 | pubmed:meshHeading | pubmed-meshheading:16095561... | lld:pubmed |
| pubmed-article:16095561 | pubmed:meshHeading | pubmed-meshheading:16095561... | lld:pubmed |
| pubmed-article:16095561 | pubmed:meshHeading | pubmed-meshheading:16095561... | lld:pubmed |
| pubmed-article:16095561 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16095561 | pubmed:articleTitle | Extensive variation in the 5'-UTR of Dicer mRNAs influences translational efficiency. | lld:pubmed |
| pubmed-article:16095561 | pubmed:affiliation | Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ont., Canada. | lld:pubmed |
| pubmed-article:16095561 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16095561 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:23405 | entrezgene:pubmed | pubmed-article:16095561 | lld:entrezgene |
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