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pubmed-article:16087865pubmed:abstractTextMice deficient in programmed cell death 1 (PD-1, Pdcd1), an immunoinhibitory receptor belonging to the CD28/cytotoxic T lymphocyte-associated antigen-4 family, spontaneously develop lupus-like autoimmune disease and autoimmune dilated cardiomyopathy on C57BL/6 and BALB/c backgrounds, respectively. However, how PD-1 deficiency induces different forms of autoimmune diseases on these two strains was unknown. Here, we report that PD-1 deficiency specifically accelerates the onset and frequency of type I diabetes in NOD (nonobese diabetic) mice, with strong T helper 1 polarization of T cells infiltrating into islets. These results suggest that PD-1 deficiency accelerates autoimmune predisposition of the background strain, leading to the induction of different forms of autoimmune diseases depending on the genetic background of the strain. Using NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes, we screened diabetes-susceptible loci by genetic linkage analysis. The diabetic incidence of NOD-Pdcd1-/- mice was controlled by five genetic loci, including three known recessive loci [Idd (insulin-dependent diabetes) 1, Idd17, and Idd20] and two previously unidentified dominant loci [Iddp (Idd under PD-1 deficiency) 1 and Iddp2].lld:pubmed
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pubmed-article:16087865pubmed:authorpubmed-author:WangJianJlld:pubmed
pubmed-article:16087865pubmed:authorpubmed-author:HonjoTasukuTlld:pubmed
pubmed-article:16087865pubmed:authorpubmed-author:HiaiHiroshiHlld:pubmed
pubmed-article:16087865pubmed:authorpubmed-author:OkazakiTakuTlld:pubmed
pubmed-article:16087865pubmed:authorpubmed-author:YoshidaTakuTlld:pubmed
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pubmed-article:16087865pubmed:pagination11823-8lld:pubmed
pubmed-article:16087865pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:16087865pubmed:articleTitleEstablishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes.lld:pubmed
pubmed-article:16087865pubmed:affiliationDepartment of Medical Chemistry and Molecular Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-ku, Kyoto 606-8501, Japan.lld:pubmed
pubmed-article:16087865pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16087865pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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