| pubmed-article:16081921 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16081921 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:16081921 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:16081921 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:16081921 | lifeskim:mentions | umls-concept:C0449557 | lld:lifeskim |
| pubmed-article:16081921 | lifeskim:mentions | umls-concept:C1257892 | lld:lifeskim |
| pubmed-article:16081921 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:16081921 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:16081921 | pubmed:dateCreated | 2005-8-5 | lld:pubmed |
| pubmed-article:16081921 | pubmed:abstractText | Verocytotoxin-producing Escherichia coli causes zoonotic food- or waterborne infection that may be associated with massive outbreaks and with the serious complication of hemolytic uremic syndrome (HUS). Serotypes O157:H7 and O157:NM are more commonly associated with HUS and outbreaks than other serotypes, such as O26:H11. To determine whether a genetic basis exists for why serotype O157:H7/NM causes HUS and outbreaks more often than other serotypes, such as O26:H11, we conducted suppression subtractive hybridization (SSH) between the genomes of the sequenced O157:H7 strain EDL933 and CL1, a clinical serotype O26:H11 isolate. Genes from four EDL933 fimbria-encoding genomic O islands (OIs) (OI-1, -47, -141, and -154) were identified in the SSH library. OI-47 encodes several additional putative virulence factors, including secreted and signaling proteins, a hemolysin locus, a lipoprotein, an ABC transport system, and a lipid biosynthesis locus. The distribution of the OIs was investigated by PCR and Southern hybridization (when PCR was negative) with 69 VTEC strains belonging to 39 different serotypes corresponding to 5 seropathotypes that differ in their disease and epidemic potential. The four OIs described here were distributed almost exclusively in serotypes O157:H7 and O157:NM, which indicates that they may be associated with the ability of these strains to colonize human and/or animal intestinal tracts and to cause epidemic and serious disease more frequently than other serotypes. The occurrence of the four OIs in enteropathogenic E. coli O55:H7 strains is consistent with their vertical inheritance by VTEC O157:H7/NM from this clonally related ancestor. | lld:pubmed |
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| pubmed-article:16081921 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16081921 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16081921 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16081921 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16081921 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16081921 | pubmed:issn | 0095-1137 | lld:pubmed |
| pubmed-article:16081921 | pubmed:author | pubmed-author:KarmaliMohame... | lld:pubmed |
| pubmed-article:16081921 | pubmed:author | pubmed-author:MascarenhasMa... | lld:pubmed |
| pubmed-article:16081921 | pubmed:author | pubmed-author:ShenSonghaiS | lld:pubmed |
| pubmed-article:16081921 | pubmed:author | pubmed-author:RahnKrisK | lld:pubmed |
| pubmed-article:16081921 | pubmed:author | pubmed-author:MorganRobynR | lld:pubmed |
| pubmed-article:16081921 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16081921 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:16081921 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16081921 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16081921 | pubmed:pagination | 3840-50 | lld:pubmed |
| pubmed-article:16081921 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:16081921 | pubmed:meshHeading | pubmed-meshheading:16081921... | lld:pubmed |
| pubmed-article:16081921 | pubmed:meshHeading | pubmed-meshheading:16081921... | lld:pubmed |
| pubmed-article:16081921 | pubmed:meshHeading | pubmed-meshheading:16081921... | lld:pubmed |
| pubmed-article:16081921 | pubmed:meshHeading | pubmed-meshheading:16081921... | lld:pubmed |
| pubmed-article:16081921 | pubmed:meshHeading | pubmed-meshheading:16081921... | lld:pubmed |
| pubmed-article:16081921 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16081921 | pubmed:articleTitle | Identification of four fimbria-encoding genomic islands that are highly specific for verocytotoxin-producing Escherichia coli serotype O157 strains. | lld:pubmed |
| pubmed-article:16081921 | pubmed:affiliation | Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, 110 Stone Road West, Guelph, Ontario, Canada, N1G 3W4. | lld:pubmed |
| pubmed-article:16081921 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16081921 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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