| pubmed-article:16077201 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:16077201 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:16077201 | lifeskim:mentions | umls-concept:C0596890 | lld:lifeskim |
| pubmed-article:16077201 | lifeskim:mentions | umls-concept:C0004391 | lld:lifeskim |
| pubmed-article:16077201 | lifeskim:mentions | umls-concept:C0006812 | lld:lifeskim |
| pubmed-article:16077201 | lifeskim:mentions | umls-concept:C0007428 | lld:lifeskim |
| pubmed-article:16077201 | lifeskim:mentions | umls-concept:C0332157 | lld:lifeskim |
| pubmed-article:16077201 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:16077201 | lifeskim:mentions | umls-concept:C1332410 | lld:lifeskim |
| pubmed-article:16077201 | lifeskim:mentions | umls-concept:C0585361 | lld:lifeskim |
| pubmed-article:16077201 | lifeskim:mentions | umls-concept:C1707719 | lld:lifeskim |
| pubmed-article:16077201 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:16077201 | pubmed:dateCreated | 2005-8-3 | lld:pubmed |
| pubmed-article:16077201 | pubmed:abstractText | The details of molecular switching points between apoptosis and autophagy in tumor cells have still not been fully elucidated. This study focused on the role of cathepsin B and its substrate, BID as molecular links between apoptosis and autophagy in human breast cancer MCF-7 cells exposed to camptothecin. Apoptosis occurred rapidly with a peak in 60 min after drug administration, whereas autophagy developed at a much slower rate with continuous progression during 24 h of cell exposure to the drug. CPT induced very rapid activation of cathepsin B. Inhibition of cathepsins by E64d prevented CPT-induced BAX and BID aggregation on mitochondria and reduced significantly reduced apoptotic cell number. The above effects were accompanied by an increase in autophagosome formation, measured by expression of MAP I LC3. BID knock down resulted in strong suppression of CPT-induced apoptosis and a shift of cell death towards autophagy, manifesting with an increase of Beclin 1 and MAP I LC3 cellular content. | lld:pubmed |
| pubmed-article:16077201 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16077201 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16077201 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16077201 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16077201 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16077201 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16077201 | pubmed:issn | 1899-1505 | lld:pubmed |
| pubmed-article:16077201 | pubmed:author | pubmed-author:GajkowskaBB | lld:pubmed |
| pubmed-article:16077201 | pubmed:author | pubmed-author:MotylTT | lld:pubmed |
| pubmed-article:16077201 | pubmed:author | pubmed-author:Lamparska-Prz... | lld:pubmed |
| pubmed-article:16077201 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16077201 | pubmed:volume | 56 Suppl 3 | lld:pubmed |
| pubmed-article:16077201 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16077201 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16077201 | pubmed:pagination | 159-79 | lld:pubmed |
| pubmed-article:16077201 | pubmed:dateRevised | 2008-5-19 | lld:pubmed |
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| pubmed-article:16077201 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16077201 | pubmed:articleTitle | Cathepsins and BID are involved in the molecular switch between apoptosis and autophagy in breast cancer MCF-7 cells exposed to camptothecin. | lld:pubmed |
| pubmed-article:16077201 | pubmed:affiliation | Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw Agricultural University, Warsaw, Poland. | lld:pubmed |
| pubmed-article:16077201 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16077201 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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