| pubmed-article:16076885 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16076885 | lifeskim:mentions | umls-concept:C1882071 | lld:lifeskim |
| pubmed-article:16076885 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:16076885 | lifeskim:mentions | umls-concept:C0699794 | lld:lifeskim |
| pubmed-article:16076885 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:16076885 | pubmed:dateCreated | 2005-10-11 | lld:pubmed |
| pubmed-article:16076885 | pubmed:abstractText | MOTIVATION: Sequence similarity often suggests evolutionary relationships between protein sequences that can be important for inferring similarity of structure or function. The most widely-used pairwise sequence comparison algorithms for homology detection, such as BLAST and PSI-BLAST, often fail to detect less conserved remotely-related targets. RESULTS: In this paper, we propose a new general graph-based propagation algorithm called MotifProp to detect more subtle similarity relationships than pairwise comparison methods. MotifProp is based on a protein-motif network, in which edges connect proteins and the k-mer based motif features that they contain. We show that our new motif-based propagation algorithm can improve the ranking results over a base algorithm, such as PSI-BLAST, that is used to initialize the ranking. Despite the complex structure of the protein-motif network, MotifProp can be easily interpreted using the top-ranked motifs and motif-rich regions induced by the propagation, both of which are helpful for discovering conserved structural components in remote homologies. | lld:pubmed |
| pubmed-article:16076885 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16076885 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16076885 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16076885 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16076885 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16076885 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16076885 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16076885 | pubmed:issn | 1367-4803 | lld:pubmed |
| pubmed-article:16076885 | pubmed:author | pubmed-author:NobleWilliam... | lld:pubmed |
| pubmed-article:16076885 | pubmed:author | pubmed-author:LeslieChristi... | lld:pubmed |
| pubmed-article:16076885 | pubmed:author | pubmed-author:WestonJasonJ | lld:pubmed |
| pubmed-article:16076885 | pubmed:author | pubmed-author:KuangRuiR | lld:pubmed |
| pubmed-article:16076885 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16076885 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16076885 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:16076885 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16076885 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16076885 | pubmed:pagination | 3711-8 | lld:pubmed |
| pubmed-article:16076885 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:16076885 | pubmed:meshHeading | pubmed-meshheading:16076885... | lld:pubmed |
| pubmed-article:16076885 | pubmed:meshHeading | pubmed-meshheading:16076885... | lld:pubmed |
| pubmed-article:16076885 | pubmed:meshHeading | pubmed-meshheading:16076885... | lld:pubmed |
| pubmed-article:16076885 | pubmed:meshHeading | pubmed-meshheading:16076885... | lld:pubmed |
| pubmed-article:16076885 | pubmed:meshHeading | pubmed-meshheading:16076885... | lld:pubmed |
| pubmed-article:16076885 | pubmed:meshHeading | pubmed-meshheading:16076885... | lld:pubmed |
| pubmed-article:16076885 | pubmed:meshHeading | pubmed-meshheading:16076885... | lld:pubmed |
| pubmed-article:16076885 | pubmed:meshHeading | pubmed-meshheading:16076885... | lld:pubmed |
| pubmed-article:16076885 | pubmed:meshHeading | pubmed-meshheading:16076885... | lld:pubmed |
| pubmed-article:16076885 | pubmed:meshHeading | pubmed-meshheading:16076885... | lld:pubmed |
| pubmed-article:16076885 | pubmed:meshHeading | pubmed-meshheading:16076885... | lld:pubmed |
| pubmed-article:16076885 | pubmed:meshHeading | pubmed-meshheading:16076885... | lld:pubmed |
| pubmed-article:16076885 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16076885 | pubmed:articleTitle | Motif-based protein ranking by network propagation. | lld:pubmed |
| pubmed-article:16076885 | pubmed:affiliation | Department of Computer Science, Columbia University New York, NY 10027, USA. | lld:pubmed |
| pubmed-article:16076885 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16076885 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:16076885 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:16076885 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16076885 | pubmed:publicationType | Evaluation Studies | lld:pubmed |
| pubmed-article:16076885 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16076885 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16076885 | lld:pubmed |
