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pubmed-article:1605854pubmed:abstractTextThe genome of Mus domesticus has multiple genes of the alpha 1-acid glycoprotein (AGP). Two cDNA clones were identified corresponding to AGP-1 and AGP-2. Moreover, two alleles of AGP-1 exist in inbred mice. The genomic DNA of the AGP-2 gene has been cloned and studied. Here we report the genomic organization of three M. domesticus AGP genes, the sequence analysis of the AGP-3 genomic DNA, and the expression of the AGP-3 gene. The major structural differences between AGP-2 and AGP-3 genes are located in introns 1 and 5. The low level of AGP-3 mRNA can be detected by the polymerase chain reaction (PCR). The molecular basis of the low level expression of AGP-3 and the possible classification of AGP-3 as a pseudogene are discussed.lld:pubmed
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pubmed-article:1605854pubmed:authorpubmed-author:ChangC JCJlld:pubmed
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pubmed-article:1605854pubmed:pagination315-20lld:pubmed
pubmed-article:1605854pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:1605854pubmed:articleTitleStructure and expression of mouse alpha 1-acid glycoprotein gene-3 (AGP-3).lld:pubmed
pubmed-article:1605854pubmed:affiliationInstitute of Biological Chemistry, National Taiwan University, Taipei.lld:pubmed
pubmed-article:1605854pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1605854pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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