| pubmed-article:16055729 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16055729 | lifeskim:mentions | umls-concept:C0034865 | lld:lifeskim |
| pubmed-article:16055729 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:16055729 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16055729 | lifeskim:mentions | umls-concept:C0221102 | lld:lifeskim |
| pubmed-article:16055729 | lifeskim:mentions | umls-concept:C0037863 | lld:lifeskim |
| pubmed-article:16055729 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:16055729 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:16055729 | lifeskim:mentions | umls-concept:C0733511 | lld:lifeskim |
| pubmed-article:16055729 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:16055729 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:16055729 | lifeskim:mentions | umls-concept:C0870411 | lld:lifeskim |
| pubmed-article:16055729 | lifeskim:mentions | umls-concept:C0243067 | lld:lifeskim |
| pubmed-article:16055729 | lifeskim:mentions | umls-concept:C0205280 | lld:lifeskim |
| pubmed-article:16055729 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:16055729 | pubmed:dateCreated | 2005-8-1 | lld:pubmed |
| pubmed-article:16055729 | pubmed:abstractText | Fundamentally different recombination defects cause apoptosis of mouse spermatocytes at the same stage in development, stage IV of the seminiferous epithelium cycle, equivalent to mid-pachynema in normal males. To understand the cellular response(s) that triggers apoptosis, we examined markers of spermatocyte development in mice with different recombination defects. In Spo11(-)(/)(-) mutants, which lack the double-strand breaks (DSBs) that initiate recombination, spermatocytes express markers of early to mid-pachynema, forming chromatin domains that contain sex body-associated proteins but that rarely encompass the sex chromosomes. Dmc1(-)(/)(-) spermatocytes, impaired in DSB repair, appear to arrest at or about late zygonema. Epistasis analysis reveals that this earlier arrest is a response to unrepaired DSBs, and cytological analysis implicates the BRCT-containing checkpoint protein TOPBP1. Atm(-)(/)(-) spermatocytes show similarities to Dmc1(-)(/)(-) spermatocytes, suggesting that ATM promotes meiotic DSB repair. Msh5(-)(/)(-) mutants display a set of characteristics distinct from these other mutants. Thus, despite equivalent stages of spermatocyte elimination, different recombination-defective mutants manifest distinct responses, providing insight into surveillance mechanisms in male meiosis. | lld:pubmed |
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| pubmed-article:16055729 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16055729 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16055729 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16055729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16055729 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16055729 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16055729 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:16055729 | pubmed:author | pubmed-author:de... | lld:pubmed |
| pubmed-article:16055729 | pubmed:author | pubmed-author:KeeneyScottS | lld:pubmed |
| pubmed-article:16055729 | pubmed:author | pubmed-author:BaudatFrédéri... | lld:pubmed |
| pubmed-article:16055729 | pubmed:author | pubmed-author:JasinMariaM | lld:pubmed |
| pubmed-article:16055729 | pubmed:author | pubmed-author:BurgoynePaul... | lld:pubmed |
| pubmed-article:16055729 | pubmed:author | pubmed-author:BarchiMarcoM | lld:pubmed |
| pubmed-article:16055729 | pubmed:author | pubmed-author:Di... | lld:pubmed |
| pubmed-article:16055729 | pubmed:author | pubmed-author:MahadevaiahSh... | lld:pubmed |
| pubmed-article:16055729 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16055729 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:16055729 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16055729 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16055729 | pubmed:pagination | 7203-15 | lld:pubmed |
| pubmed-article:16055729 | pubmed:dateRevised | 2011-3-28 | lld:pubmed |
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| pubmed-article:16055729 | pubmed:meshHeading | pubmed-meshheading:16055729... | lld:pubmed |
