Statements in which the resource exists.
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pubmed-article:16055052pubmed:dateCreated2005-8-1lld:pubmed
pubmed-article:16055052pubmed:abstractTextThe chemical diagnosis of tyrosinemia type I generally involves the detection of succinylacetone (SA) in patient urine. However, 5-aminolevulinate (5ALA), which accumulates due to succinylacetone's inhibition of porphyrin synthesis, can also be used as diagnostic metabolites. Here we examined the stabilities of these markers on dried urine filter paper. After two weeks at room temperature, the succinylacetone was 10% of its original level, but over 80% of 5-aminolevulinate remained. Thus, although insufficient succinylacetone was recovered from dried urine filter paper to diagnose tyrosinemia type I, 5-aminolevulinate was readily detected, permitting the diagnosis.lld:pubmed
pubmed-article:16055052pubmed:languageenglld:pubmed
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pubmed-article:16055052pubmed:statusMEDLINElld:pubmed
pubmed-article:16055052pubmed:monthAuglld:pubmed
pubmed-article:16055052pubmed:issn1570-0232lld:pubmed
pubmed-article:16055052pubmed:authorpubmed-author:ShinkaToshihi...lld:pubmed
pubmed-article:16055052pubmed:authorpubmed-author:InoueYoshitoYlld:pubmed
pubmed-article:16055052pubmed:authorpubmed-author:OhseMorimasaMlld:pubmed
pubmed-article:16055052pubmed:authorpubmed-author:KuharaTomikoTlld:pubmed
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pubmed-article:16055052pubmed:pagination44-6lld:pubmed
pubmed-article:16055052pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:16055052pubmed:year2005lld:pubmed
pubmed-article:16055052pubmed:articleTitleStability of 5-aminolevulinic acid on dried urine filter paper for a diagnostic marker of tyrosinemia type I.lld:pubmed
pubmed-article:16055052pubmed:affiliationDivision of Human Genetics, Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku-gun, Ishikawa 920-0293, Japan.lld:pubmed
pubmed-article:16055052pubmed:publicationTypeJournal Articlelld:pubmed