| pubmed-article:16054130 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16054130 | lifeskim:mentions | umls-concept:C0242358 | lld:lifeskim |
| pubmed-article:16054130 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:16054130 | lifeskim:mentions | umls-concept:C1179464 | lld:lifeskim |
| pubmed-article:16054130 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16054130 | pubmed:dateCreated | 2005-9-19 | lld:pubmed |
| pubmed-article:16054130 | pubmed:abstractText | We recently described that in the metastasizing rat pancreatic carcinoma line BSp73ASML the cell-cell adhesion molecule EpCAM, CD44 variant isoforms and the tetraspanins D6.1A and CD9 form a complex that is located in glycolipid-enriched membrane microdomains. This complex contains, in addition, an undefined 20 kDa protein. As such complex formation influenced cell-cell adhesion and apoptosis resistance, it became of interest to identify the 20 kDa polypeptide. This 20 kDa protein, which co-precipitated with EpCAM in BSp73ASML lysates, was identified as the tight junction protein claudin-7. Correspondingly, an association between EpCAM and claudin-7 was noted in rat and human tumors and in non-transformed tissues of the gastrointestinal tract. Co-localization of the two molecules was most pronounced at basolateral membranes, but was also observed in tight junctions. Evidence for direct protein-protein interactions between EpCAM and claudin-7 was obtained by co-immunoprecipitation after treatment of tumor cells with a membrane-permeable chemical cross-linker. The complex, which is located in glycolipid-enriched membrane microdomains, is not disrupted by partial cholesterol depletion, but claudin-7 phosphorylation is restricted to the localization in glycolipid-enriched membrane microdomains. This is the first report on an association between EpCAM and claudins in both non-transformed tissues and metastasizing tumor cell lines. | lld:pubmed |
| pubmed-article:16054130 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16054130 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16054130 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16054130 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16054130 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16054130 | pubmed:issn | 0014-4827 | lld:pubmed |
| pubmed-article:16054130 | pubmed:author | pubmed-author:LangbeinLutzL | lld:pubmed |
| pubmed-article:16054130 | pubmed:author | pubmed-author:SchmidtDirk-S... | lld:pubmed |
| pubmed-article:16054130 | pubmed:author | pubmed-author:ZöllerMargotM | lld:pubmed |
| pubmed-article:16054130 | pubmed:author | pubmed-author:FrankeWerner... | lld:pubmed |
| pubmed-article:16054130 | pubmed:author | pubmed-author:SchnölzerMart... | lld:pubmed |
| pubmed-article:16054130 | pubmed:author | pubmed-author:MoldenhauerGe... | lld:pubmed |
| pubmed-article:16054130 | pubmed:author | pubmed-author:FiedlerSabine... | lld:pubmed |
| pubmed-article:16054130 | pubmed:author | pubmed-author:PapeUlrich-Fr... | lld:pubmed |
| pubmed-article:16054130 | pubmed:author | pubmed-author:LadweinMarkus... | lld:pubmed |
| pubmed-article:16054130 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16054130 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16054130 | pubmed:volume | 309 | lld:pubmed |
| pubmed-article:16054130 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16054130 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16054130 | pubmed:pagination | 345-57 | lld:pubmed |
| pubmed-article:16054130 | pubmed:dateRevised | 2011-10-28 | lld:pubmed |
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| pubmed-article:16054130 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16054130 | pubmed:articleTitle | The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7. | lld:pubmed |
| pubmed-article:16054130 | pubmed:affiliation | Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany. | lld:pubmed |
| pubmed-article:16054130 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16054130 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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