| pubmed-article:16051604 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16051604 | lifeskim:mentions | umls-concept:C1314972 | lld:lifeskim |
| pubmed-article:16051604 | lifeskim:mentions | umls-concept:C0225369 | lld:lifeskim |
| pubmed-article:16051604 | lifeskim:mentions | umls-concept:C0076560 | lld:lifeskim |
| pubmed-article:16051604 | lifeskim:mentions | umls-concept:C0021701 | lld:lifeskim |
| pubmed-article:16051604 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:16051604 | lifeskim:mentions | umls-concept:C0601900 | lld:lifeskim |
| pubmed-article:16051604 | lifeskim:mentions | umls-concept:C1456376 | lld:lifeskim |
| pubmed-article:16051604 | lifeskim:mentions | umls-concept:C0237497 | lld:lifeskim |
| pubmed-article:16051604 | lifeskim:mentions | umls-concept:C0185023 | lld:lifeskim |
| pubmed-article:16051604 | lifeskim:mentions | umls-concept:C0183683 | lld:lifeskim |
| pubmed-article:16051604 | lifeskim:mentions | umls-concept:C1947904 | lld:lifeskim |
| pubmed-article:16051604 | lifeskim:mentions | umls-concept:C1999228 | lld:lifeskim |
| pubmed-article:16051604 | lifeskim:mentions | umls-concept:C2825781 | lld:lifeskim |
| pubmed-article:16051604 | pubmed:issue | 38 | lld:pubmed |
| pubmed-article:16051604 | pubmed:dateCreated | 2005-9-19 | lld:pubmed |
| pubmed-article:16051604 | pubmed:abstractText | Cartilage oligomeric matrix protein/thrombospondin 5 (COMP/TSP5) is a major component of the extracellular matrix of the musculoskeletal system. Although COMP/TSP5 abnormalities are associated with several pathological conditions, its normal function remains unclear. This study was undertaken to delineate the function(s) of COMP/TSP5 in cartilage, especially regarding its interaction with chondrocytes. We show that COMP/TSP5 can support chondrocyte attachment and that the RGD sequence in COMP/TSP5 and the integrin receptors alpha5beta1 and alphaVbeta3 on the chondrocytes are involved in mediating this attachment. The interactions of COMP/TSP5 with the integrins are dependent on COMP/TSP5 conformation. Chondrocyte attachment to COMP/TSP5 in the calcium-replete conformation was inhibited by function-blocking integrin alpha5 and beta1 antibodies, suggesting the involvement of the alpha5beta1 integrin. Under this condition, a function-blocking antibody against alphaVbeta3 did not have any effect on cell attachment. On the other hand, chondrocyte attachment to reduced COMP/TSP5 was instead sensitive to alphaVbeta3 function-blocking antibodies, suggesting that COMP/TSP5 mediates attachment through chondrocyte alphaVbeta3 integrin under this condition. Cell attachment to reduced COMP/TSP5 was not inhibited by beta1 antibodies. These data indicate that COMP/TSP5 in different conformations can utilize different integrin receptors. These results are the first to demonstrate that COMP/TSP5 can mediate chondrocyte attachment through interactions with integrins. Through these interactions, COMP/TSP5 may be able to regulate cellular activities and respond to environment in the surrounding cartilage matrix. | lld:pubmed |
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| pubmed-article:16051604 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16051604 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16051604 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16051604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16051604 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16051604 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16051604 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:16051604 | pubmed:author | pubmed-author:HechtJacqueli... | lld:pubmed |
| pubmed-article:16051604 | pubmed:author | pubmed-author:GoldringMary... | lld:pubmed |
| pubmed-article:16051604 | pubmed:author | pubmed-author:LawlerJackJ | lld:pubmed |
| pubmed-article:16051604 | pubmed:author | pubmed-author:ChenFaye... | lld:pubmed |
| pubmed-article:16051604 | pubmed:author | pubmed-author:ThomasAshby... | lld:pubmed |
| pubmed-article:16051604 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16051604 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:16051604 | pubmed:volume | 280 | lld:pubmed |
