Linked Life Data

16046222

Source:http://linkedlifedata.com/resource/pubmed/id/16046222

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:16046222rdf:typepubmed:Citationlld:pubmed
pubmed-article:16046222lifeskim:mentionsumls-concept:C0032105lld:lifeskim
pubmed-article:16046222lifeskim:mentionsumls-concept:C0010068lld:lifeskim
pubmed-article:16046222lifeskim:mentionsumls-concept:C1527148lld:lifeskim
pubmed-article:16046222lifeskim:mentionsumls-concept:C0071973lld:lifeskim
pubmed-article:16046222lifeskim:mentionsumls-concept:C2603343lld:lifeskim
pubmed-article:16046222pubmed:issue2lld:pubmed
pubmed-article:16046222pubmed:dateCreated2006-3-6lld:pubmed
pubmed-article:16046222pubmed:abstractTextThe pathogenesis of ischemic coronary events involves degradation of the extracellular matrix in atherosclerotic lesions. The cysteine protease inhibitor cystatin-C may be involved in this phenomenon. The association of plasma cystatin-C with the incidence of myocardial infarction-coronary death and angina, was examined in a nested case-control (two controls per case) design within the prospective cohort study (Prospective Epidemiological Study of Myocardial Infarction (PRIME Study)) which included 9,758 men aged 50-59 years who were free of coronary heart disease (CHD) on entry and followed for a 5-year period. Three hundred and thirteen participants suffered myocardial infarction or coronary death (n = 159) or angina pectoris (n = 154) during follow-up. Cystatin-C was positively correlated with body mass index (BMI), low-density lipoprotein (LDL)-cholesterol, triglycerides and several inflammatory markers such as fibrinogen (r = 0.18), C-reactive protein (CRP) (r = 0.24), interleukin-6 (= 0.20), tumor necrosis factor-alpha (TNFalpha) (r = 0.27) and two TNFalpha receptors: TNFR1A (r = 0.43) and TNFR1B (r = 0.41); and negatively with high-density lipoprotein (HDL)-cholesterol (r = -0.25). After adjustment for traditional risk factors (age, diabetes, smoking, hypertension, BMI, triglycerides, LDL- and HDL-cholesterol), cystatin-C was significantly associated with the occurrence of the first ischemic coronary event. However, this association was no longer significant when CRP was included in the analysis. A decrease in glomerular filtration rate did not explain higher cystatin-C in cases than in controls. Cystatin-C appears to participate in the inflammatory phenomenon observed in the atherosclerotic process. Cystatin-C is not a more predictive risk marker of CHD than CRP or interleukin-6, but could be useful in detecting moderate chronic renal disease.lld:pubmed
pubmed-article:16046222pubmed:languageenglld:pubmed
pubmed-article:16046222pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16046222pubmed:citationSubsetIMlld:pubmed
pubmed-article:16046222pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16046222pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16046222pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16046222pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16046222pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16046222pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16046222pubmed:statusMEDLINElld:pubmed
pubmed-article:16046222pubmed:monthAprlld:pubmed
pubmed-article:16046222pubmed:issn0021-9150lld:pubmed
pubmed-article:16046222pubmed:authorpubmed-author:PRIME Study...lld:pubmed
pubmed-article:16046222pubmed:authorpubmed-author:Juhan-VagueIr...lld:pubmed
pubmed-article:16046222pubmed:authorpubmed-author:EvansAlunAlld:pubmed
pubmed-article:16046222pubmed:authorpubmed-author:ArveilerDomin...lld:pubmed
pubmed-article:16046222pubmed:authorpubmed-author:LucGéraldGlld:pubmed
pubmed-article:16046222pubmed:authorpubmed-author:AmouyelPhilip...lld:pubmed
pubmed-article:16046222pubmed:authorpubmed-author:FruchartJean-...lld:pubmed
pubmed-article:16046222pubmed:authorpubmed-author:FerrieresJean...lld:pubmed
pubmed-article:16046222pubmed:authorpubmed-author:BardJean-Mari...lld:pubmed
pubmed-article:16046222pubmed:authorpubmed-author:DucimetierePi...lld:pubmed
pubmed-article:16046222pubmed:authorpubmed-author:LesueurCéline...lld:pubmed
pubmed-article:16046222pubmed:issnTypePrintlld:pubmed
pubmed-article:16046222pubmed:volume185lld:pubmed
pubmed-article:16046222pubmed:ownerNLMlld:pubmed
pubmed-article:16046222pubmed:authorsCompleteYlld:pubmed
pubmed-article:16046222pubmed:pagination375-80lld:pubmed
pubmed-article:16046222pubmed:dateRevised2008-11-21lld:pubmed
pubmed-article:16046222pubmed:meshHeadingpubmed-meshheading:16046222...lld:pubmed
pubmed-article:16046222pubmed:meshHeadingpubmed-meshheading:16046222...lld:pubmed
pubmed-article:16046222pubmed:meshHeadingpubmed-meshheading:16046222...lld:pubmed
pubmed-article:16046222pubmed:meshHeadingpubmed-meshheading:16046222...lld:pubmed
pubmed-article:16046222pubmed:meshHeadingpubmed-meshheading:16046222...lld:pubmed
pubmed-article:16046222pubmed:meshHeadingpubmed-meshheading:16046222...lld:pubmed
pubmed-article:16046222pubmed:meshHeadingpubmed-meshheading:16046222...lld:pubmed
pubmed-article:16046222pubmed:meshHeadingpubmed-meshheading:16046222...lld:pubmed
pubmed-article:16046222pubmed:meshHeadingpubmed-meshheading:16046222...lld:pubmed
pubmed-article:16046222pubmed:meshHeadingpubmed-meshheading:16046222...lld:pubmed
pubmed-article:16046222pubmed:meshHeadingpubmed-meshheading:16046222...lld:pubmed
pubmed-article:16046222pubmed:meshHeadingpubmed-meshheading:16046222...lld:pubmed
pubmed-article:16046222pubmed:meshHeadingpubmed-meshheading:16046222...lld:pubmed
pubmed-article:16046222pubmed:year2006lld:pubmed
pubmed-article:16046222pubmed:articleTitlePlasma cystatin-C and development of coronary heart disease: The PRIME Study.lld:pubmed
pubmed-article:16046222pubmed:affiliationDepartment of Atherosclerosis, SERLIA-INSERM UR545, Institut Pasteur de Lille, 1, rue du Professeur Calmette, 59019 Lille Cedex, France and University Lille II, France. Gerald.Luc@pasteur-lille.frlld:pubmed
pubmed-article:16046222pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16046222pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16046222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16046222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16046222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16046222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16046222lld:pubmed