| pubmed-article:16043519 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16043519 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:16043519 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:16043519 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:16043519 | lifeskim:mentions | umls-concept:C0004368 | lld:lifeskim |
| pubmed-article:16043519 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:16043519 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:16043519 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:16043519 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16043519 | pubmed:dateCreated | 2005-8-2 | lld:pubmed |
| pubmed-article:16043519 | pubmed:abstractText | Identification of the T cell immunoglobulin mucin-domain containing (Tim) gene family introduced a new family of cell surface molecules that is involved in the regulation of immune responses. We previously demonstrated that Tim-3 is expressed on terminally differentiated T helper (Th)1 cells, and serves to regulate Th1 immune responses. Here, we describe the identification and function of Tim-2, a novel member of the Tim gene family. In contrast with Tim-3, we demonstrate that Tim-2 is expressed preferentially in differentiated Th2 cells. Blockade of the Tim-2/Tim-2 ligand interaction, by administration of soluble Tim-2 fusion protein (Tim-2 immunoglobulin [Ig]), results in T cell hyperproliferation and the production of Th2 cytokines. Administration of Tim-2 Ig during the induction phase reduces the severity of experimental autoimmune encephalomyelitis, a Th1-mediated autoimmune disease model of multiple sclerosis. We propose that Tim-2, an orthologue of human Tim-1, is critical for the regulation of Th2 responses during autoimmune inflammation. | lld:pubmed |
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| pubmed-article:16043519 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16043519 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16043519 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16043519 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16043519 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:16043519 | pubmed:author | pubmed-author:StromTerry... | lld:pubmed |
| pubmed-article:16043519 | pubmed:author | pubmed-author:SabatosCather... | lld:pubmed |
| pubmed-article:16043519 | pubmed:author | pubmed-author:SobelRaymond... | lld:pubmed |
| pubmed-article:16043519 | pubmed:author | pubmed-author:KuchrooVijay... | lld:pubmed |
| pubmed-article:16043519 | pubmed:author | pubmed-author:ZhengXin XXX | lld:pubmed |
| pubmed-article:16043519 | pubmed:author | pubmed-author:XiaoShengS | lld:pubmed |
| pubmed-article:16043519 | pubmed:author | pubmed-author:ChakravartiSu... | lld:pubmed |
| pubmed-article:16043519 | pubmed:author | pubmed-author:IllesZsoltZ | lld:pubmed |
| pubmed-article:16043519 | pubmed:author | pubmed-author:ChaEugene KEK | lld:pubmed |
| pubmed-article:16043519 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16043519 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16043519 | pubmed:volume | 202 | lld:pubmed |
| pubmed-article:16043519 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16043519 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16043519 | pubmed:pagination | 437-44 | lld:pubmed |
| pubmed-article:16043519 | pubmed:dateRevised | 2011-11-11 | lld:pubmed |
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| pubmed-article:16043519 | pubmed:meshHeading | pubmed-meshheading:16043519... | lld:pubmed |
| pubmed-article:16043519 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16043519 | pubmed:articleTitle | Tim-2 regulates T helper type 2 responses and autoimmunity. | lld:pubmed |
| pubmed-article:16043519 | pubmed:affiliation | Department of Neurology, Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:16043519 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16043519 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:16043519 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16043519 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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