| pubmed-article:16041695 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16041695 | lifeskim:mentions | umls-concept:C0079731 | lld:lifeskim |
| pubmed-article:16041695 | lifeskim:mentions | umls-concept:C1522718 | lld:lifeskim |
| pubmed-article:16041695 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:16041695 | lifeskim:mentions | umls-concept:C0063382 | lld:lifeskim |
| pubmed-article:16041695 | lifeskim:mentions | umls-concept:C0205219 | lld:lifeskim |
| pubmed-article:16041695 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16041695 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:16041695 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:16041695 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:16041695 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16041695 | pubmed:dateCreated | 2005-9-12 | lld:pubmed |
| pubmed-article:16041695 | pubmed:abstractText | In a previous study we demonstrated high expression of the non-coding BIC gene in the vast majority of Hodgkin's lymphomas (HLs). Evidence suggesting that BIC is a primary microRNA transcript containing the mature microRNA-155 (miR-155) as part of a RNA hairpin is now accumulating. We therefore analysed HL cell lines and tissue samples to determine whether miR-155 is also expressed in HL. High levels of miR-155 could be demonstrated, indicating that BIC is processed into a microRNA in HL. Most non-HL subtypes were negative for BIC as determined by RNA-ISH. However, in diffuse large B cell lymphoma (DLBCL) and primary mediastinal B cell lymphoma (PMBL), significant percentages of positive tumour cells were observed in 12/18 and 8/8 cases. A higher proportion of tumour cells were positive for BIC in DLBCL with activated B cell-like phenotype than in DLBCL with germinal centre B cell-like phenotype. Differential BIC expression was confirmed by qRT-PCR analysis. Northern blot analysis showed expression of miR-155 in all DLBCL and PMBL derived cell lines and tissue samples analysed. In summary, we demonstrate expression of primary microRNA BIC and its derivative miR-155 in HL, PMBL and DLBCL. | lld:pubmed |
| pubmed-article:16041695 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16041695 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16041695 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16041695 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16041695 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16041695 | pubmed:issn | 0022-3417 | lld:pubmed |
| pubmed-article:16041695 | pubmed:author | pubmed-author:JacobsSusanS | lld:pubmed |
| pubmed-article:16041695 | pubmed:author | pubmed-author:PoppemaSibran... | lld:pubmed |
| pubmed-article:16041695 | pubmed:author | pubmed-author:van den... | lld:pubmed |
| pubmed-article:16041695 | pubmed:author | pubmed-author:de... | lld:pubmed |
| pubmed-article:16041695 | pubmed:author | pubmed-author:KroesenBart-J... | lld:pubmed |
| pubmed-article:16041695 | pubmed:author | pubmed-author:BlokzijlTjass... | lld:pubmed |
| pubmed-article:16041695 | pubmed:author | pubmed-author:KluiverJoostJ | lld:pubmed |
| pubmed-article:16041695 | pubmed:author | pubmed-author:HarmsGeertG | lld:pubmed |
| pubmed-article:16041695 | pubmed:copyrightInfo | Copyright (c) 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. | lld:pubmed |
| pubmed-article:16041695 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16041695 | pubmed:volume | 207 | lld:pubmed |
| pubmed-article:16041695 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16041695 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16041695 | pubmed:pagination | 243-9 | lld:pubmed |
| pubmed-article:16041695 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:16041695 | pubmed:meshHeading | pubmed-meshheading:16041695... | lld:pubmed |
| pubmed-article:16041695 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16041695 | pubmed:articleTitle | BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas. | lld:pubmed |
| pubmed-article:16041695 | pubmed:affiliation | Department of Pathology and Laboratory Medicine, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands. | lld:pubmed |
| pubmed-article:16041695 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16041695 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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