| pubmed-article:16040962 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16040962 | lifeskim:mentions | umls-concept:C0004611 | lld:lifeskim |
| pubmed-article:16040962 | lifeskim:mentions | umls-concept:C0018154 | lld:lifeskim |
| pubmed-article:16040962 | lifeskim:mentions | umls-concept:C0037278 | lld:lifeskim |
| pubmed-article:16040962 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
| pubmed-article:16040962 | lifeskim:mentions | umls-concept:C0023779 | lld:lifeskim |
| pubmed-article:16040962 | lifeskim:mentions | umls-concept:C0670896 | lld:lifeskim |
| pubmed-article:16040962 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:16040962 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:16040962 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:16040962 | pubmed:dateCreated | 2005-7-25 | lld:pubmed |
| pubmed-article:16040962 | pubmed:abstractText | flake (flk), an N-ethyl-N-nitrosourea-induced recessive germ line mutation of C57BL/6 mice, impairs the clearance of skin infections by Streptococcus pyogenes and Staphylococcus aureus, gram-positive pathogens that elicit innate immune responses by activating Toll-like receptor 2 (TLR2). Positional cloning and sequencing revealed that flk is a novel allele of the stearoyl coenzyme A desaturase 1 gene (Scd1). flake homozygotes show reduced sebum production and are unable to synthesize the monounsaturated fatty acids (MUFA) palmitoleate (C(16:1)) and oleate (C(18:1)), both of which are bactericidal against gram-positive (but not gram-negative) organisms in vitro. However, intradermal MUFA administration to S. aureus-infected mice partially rescues the flake phenotype, which indicates that an additional component of the sebum may be required to improve bacterial clearance. In normal mice, transcription of Scd1-a gene with numerous NF-kappaB elements in its promoter--is strongly and specifically induced by TLR2 signaling. Similarly, the SCD1 gene is induced by TLR2 signaling in a human sebocyte cell line. These observations reveal the existence of a regulated, lipid-based antimicrobial effector pathway in mammals and suggest new approaches to the treatment or prevention of infections with gram-positive bacteria. | lld:pubmed |
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| pubmed-article:16040962 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16040962 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16040962 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16040962 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16040962 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16040962 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:16040962 | pubmed:author | pubmed-author:LüZ BZB | lld:pubmed |
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| pubmed-article:16040962 | pubmed:author | pubmed-author:JiangZhengfan... | lld:pubmed |
| pubmed-article:16040962 | pubmed:author | pubmed-author:GeorgelPhilip... | lld:pubmed |
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| pubmed-article:16040962 | pubmed:author | pubmed-author:CrozatKarineK | lld:pubmed |
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| pubmed-article:16040962 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16040962 | pubmed:volume | 73 | lld:pubmed |
| pubmed-article:16040962 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16040962 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16040962 | pubmed:pagination | 4512-21 | lld:pubmed |
| pubmed-article:16040962 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:16040962 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16040962 | pubmed:articleTitle | A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria. | lld:pubmed |
| pubmed-article:16040962 | pubmed:affiliation | Department of Immunology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA. | lld:pubmed |
| pubmed-article:16040962 | pubmed:publicationType | Journal Article | lld:pubmed |
