| pubmed-article:16035616 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16035616 | lifeskim:mentions | umls-concept:C0597032 | lld:lifeskim |
| pubmed-article:16035616 | lifeskim:mentions | umls-concept:C0007082 | lld:lifeskim |
| pubmed-article:16035616 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:16035616 | lifeskim:mentions | umls-concept:C0007620 | lld:lifeskim |
| pubmed-article:16035616 | lifeskim:mentions | umls-concept:C0431085 | lld:lifeskim |
| pubmed-article:16035616 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:16035616 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:16035616 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:16035616 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:16035616 | pubmed:dateCreated | 2005-7-22 | lld:pubmed |
| pubmed-article:16035616 | pubmed:abstractText | Most circulating tumor cells die within 24 h of entering the hepatic microvasculature because their arrest initiates an ischemia-reperfusion (I/R) injury that is cytotoxic. Human colorectal carcinomas (CRC) produce the glycoprotein Carcinoembryonic Antigen (CEA) that increases experimental liver metastasis in nude mice. Since CEA induces release of IL-6 and IL-10, we hypothesized that CEA inhibits the I/R injury through a Kupffer cell-mediated cytokine-dependent pathway. We assessed cytokine effects in CRC co-cultured with liver and in vivo. Human CRC prelabeled with fluorescent dyes were incubated with a reoxygenated suspension of ischemic nude mouse liver fragments in a bioreactor. CEA, rhIL-6 or rhIL-10 were either administered to the donor mice prior to hepatic ischemia or during co-culture. Liver donors were athymic nude or iNOS, IL-6 or IL-10 knock out mice. Ischemic-reoxygenated liver kills Clone A CRC through production of nitric oxide (NO) and superoxide anion. Treatment of liver donors with CEA prior to hepatic ischemia inhibited this in vitro cytotoxicity through an IL-10 and Kupffer cell dependent pathway that inhibited NF-kappaB activation, NO production and iNOS upregulation. IL-10 but not IL-6 enhanced CRC survival in nude mouse liver in vivo. Thus, CEA enhanced metastasis by inducing IL-10 to inhibit iNOS upregulation in host liver. | lld:pubmed |
| pubmed-article:16035616 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16035616 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16035616 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16035616 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16035616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16035616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16035616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16035616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16035616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16035616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16035616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16035616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16035616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16035616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16035616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16035616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16035616 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16035616 | pubmed:issn | 0262-0898 | lld:pubmed |
| pubmed-article:16035616 | pubmed:author | pubmed-author:SamaraRR | lld:pubmed |
| pubmed-article:16035616 | pubmed:author | pubmed-author:BattlePP | lld:pubmed |
| pubmed-article:16035616 | pubmed:author | pubmed-author:JessupJ... | lld:pubmed |
| pubmed-article:16035616 | pubmed:author | pubmed-author:LaguingeL MLM | lld:pubmed |
| pubmed-article:16035616 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16035616 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:16035616 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16035616 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16035616 | pubmed:pagination | 709-17 | lld:pubmed |
| pubmed-article:16035616 | pubmed:dateRevised | 2011-10-27 | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:meshHeading | pubmed-meshheading:16035616... | lld:pubmed |
| pubmed-article:16035616 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:16035616 | pubmed:articleTitle | Carcinoembryonic antigen promotes tumor cell survival in liver through an IL-10-dependent pathway. | lld:pubmed |
| pubmed-article:16035616 | pubmed:affiliation | Department of Oncology, Georgetown University Medical Center, Washington, DC, USA. jmj25@georgetown.edu | lld:pubmed |
| pubmed-article:16035616 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16035616 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:16035616 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:16035616 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:25325 | entrezgene:pubmed | pubmed-article:16035616 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16035616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16035616 | lld:pubmed |
