| pubmed-article:16034098 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16034098 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:16034098 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:16034098 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:16034098 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:16034098 | lifeskim:mentions | umls-concept:C1823153 | lld:lifeskim |
| pubmed-article:16034098 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:16034098 | lifeskim:mentions | umls-concept:C0439097 | lld:lifeskim |
| pubmed-article:16034098 | lifeskim:mentions | umls-concept:C2349976 | lld:lifeskim |
| pubmed-article:16034098 | lifeskim:mentions | umls-concept:C1552644 | lld:lifeskim |
| pubmed-article:16034098 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:16034098 | lifeskim:mentions | umls-concept:C1547348 | lld:lifeskim |
| pubmed-article:16034098 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:16034098 | lifeskim:mentions | umls-concept:C0205228 | lld:lifeskim |
| pubmed-article:16034098 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16034098 | pubmed:dateCreated | 2005-7-21 | lld:pubmed |
| pubmed-article:16034098 | pubmed:abstractText | Human Vgamma9Vdelta2 T cells recognize nonpeptidic Ags generated by the 1-deoxy-d-xylulose 5-phosphate (many eubacteria, algae, plants, and Apicomplexa) and mevalonate (eukaryotes, archaebacteria, and certain eubacteria) pathways of isoprenoid synthesis. The potent Vgamma9Vdelta2 T cell reactivity 1) against certain cancer cells or 2) induced by infectious agents indicates that therapeutic augmentations of Vgamma9Vdelta2 T cell activities may be clinically beneficial. The functional characteristics of Vgamma9Vdelta2 T cells from Macaca fascicularis (cynomolgus monkey) are very similar to those from Homo sapiens. We have found that the i.v. administration of nitrogen-containing bisphosphonate or pyrophosphomonoester drugs into cynomolgus monkeys combined with s.c. low-dose (6 x 10(5) U/animal) IL-2 induces a large pool of CD27+ and CD27- effector/memory T cells in the peripheral blood of treated animals. The administration of these drugs in the absence of IL-2 is substantially less effective, indicating the importance of additional exogenous costimuli. Shortly after the costimulatory IL-2 treatment, only gammadelta (but not alphabeta) T cells expressed the CD69 activation marker, indicating that Vgamma9Vdelta2 T lymphocytes are more responsive to low-dose IL-2 than alphabeta T cells. Up to 100-fold increases in the numbers of peripheral blood Vgamma9Vdelta2 T cells were observed in animals receiving the gammadelta stimulatory drug plus IL-2. Moreover, the expanded Vgamma9Vdelta2 T cells were potent Th1 effectors capable of releasing large amounts of IFN-gamma. These results may be relevant for designing novel (or modifying current) immunotherapeutic trials with nitrogen-containing bisphosphonate or pyrophosphomonoester drugs. | lld:pubmed |
| pubmed-article:16034098 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16034098 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16034098 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:16034098 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16034098 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16034098 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:16034098 | pubmed:author | pubmed-author:CasettiRitaR | lld:pubmed |
| pubmed-article:16034098 | pubmed:author | pubmed-author:ColizziVittor... | lld:pubmed |
| pubmed-article:16034098 | pubmed:author | pubmed-author:PocciaFabrizi... | lld:pubmed |
| pubmed-article:16034098 | pubmed:author | pubmed-author:D'OffiziGianp... | lld:pubmed |
| pubmed-article:16034098 | pubmed:author | pubmed-author:DieliFrancesc... | lld:pubmed |
| pubmed-article:16034098 | pubmed:author | pubmed-author:MatteiMaurizi... | lld:pubmed |
| pubmed-article:16034098 | pubmed:author | pubmed-author:PerrettaGemma... | lld:pubmed |
| pubmed-article:16034098 | pubmed:author | pubmed-author:MalkovskyMiro... | lld:pubmed |
| pubmed-article:16034098 | pubmed:author | pubmed-author:TaglioniAless... | lld:pubmed |
| pubmed-article:16034098 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16034098 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16034098 | pubmed:volume | 175 | lld:pubmed |
| pubmed-article:16034098 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16034098 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16034098 | pubmed:pagination | 1593-8 | lld:pubmed |
| pubmed-article:16034098 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:16034098 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16034098 | pubmed:articleTitle | Drug-induced expansion and differentiation of V gamma 9V delta 2 T cells in vivo: the role of exogenous IL-2. | lld:pubmed |
| pubmed-article:16034098 | pubmed:affiliation | National Institute for Infectious Diseases, Lazzaro Spallanzani, Istituto di Ricerca e Cura a Carattere Scientifico, Rome, Italy. | lld:pubmed |
| pubmed-article:16034098 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16034098 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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