| pubmed-article:16033261 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16033261 | lifeskim:mentions | umls-concept:C0031684 | lld:lifeskim |
| pubmed-article:16033261 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:16033261 | lifeskim:mentions | umls-concept:C0872079 | lld:lifeskim |
| pubmed-article:16033261 | lifeskim:mentions | umls-concept:C1418582 | lld:lifeskim |
| pubmed-article:16033261 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:16033261 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:16033261 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:16033261 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:16033261 | lifeskim:mentions | umls-concept:C1880355 | lld:lifeskim |
| pubmed-article:16033261 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:16033261 | lifeskim:mentions | umls-concept:C0065193 | lld:lifeskim |
| pubmed-article:16033261 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:16033261 | pubmed:dateCreated | 2005-7-21 | lld:pubmed |
| pubmed-article:16033261 | pubmed:abstractText | Interactions involving phosphorylated Ser/Thr-Pro motifs in proteins play a key role in numerous regulatory processes in the cell. Here, we investigate potential ligands of the WW binding domain of Pin1 in order to inhibit protein-protein interactions between Pin1 and phosphopeptides. Our structure-based strategy implies the synthesis of analogues of the Ac-Thr(PO(3)H(2))-Pro-NH(2) dipeptide and relies on high resolution NMR spectroscopy to accurately measure the affinity constants even in the high micromolar range. | lld:pubmed |
| pubmed-article:16033261 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16033261 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16033261 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16033261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16033261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16033261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16033261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16033261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16033261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16033261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16033261 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16033261 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16033261 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:16033261 | pubmed:author | pubmed-author:BuéeLucL | lld:pubmed |
| pubmed-article:16033261 | pubmed:author | pubmed-author:LippensGuyG | lld:pubmed |
| pubmed-article:16033261 | pubmed:author | pubmed-author:LandrieuIsabe... | lld:pubmed |
| pubmed-article:16033261 | pubmed:author | pubmed-author:WieruszeskiJe... | lld:pubmed |
| pubmed-article:16033261 | pubmed:author | pubmed-author:SmetCarolineC | lld:pubmed |
| pubmed-article:16033261 | pubmed:author | pubmed-author:DuckertJean-F... | lld:pubmed |
| pubmed-article:16033261 | pubmed:author | pubmed-author:DéprezBenoîtB | lld:pubmed |
| pubmed-article:16033261 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16033261 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:16033261 | pubmed:volume | 48 | lld:pubmed |
| pubmed-article:16033261 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16033261 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16033261 | pubmed:pagination | 4815-23 | lld:pubmed |
| pubmed-article:16033261 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16033261 | pubmed:meshHeading | pubmed-meshheading:16033261... | lld:pubmed |
| pubmed-article:16033261 | pubmed:meshHeading | pubmed-meshheading:16033261... | lld:pubmed |
| pubmed-article:16033261 | pubmed:meshHeading | pubmed-meshheading:16033261... | lld:pubmed |
| pubmed-article:16033261 | pubmed:meshHeading | pubmed-meshheading:16033261... | lld:pubmed |
| pubmed-article:16033261 | pubmed:meshHeading | pubmed-meshheading:16033261... | lld:pubmed |
| pubmed-article:16033261 | pubmed:meshHeading | pubmed-meshheading:16033261... | lld:pubmed |
| pubmed-article:16033261 | pubmed:meshHeading | pubmed-meshheading:16033261... | lld:pubmed |
| pubmed-article:16033261 | pubmed:meshHeading | pubmed-meshheading:16033261... | lld:pubmed |
| pubmed-article:16033261 | pubmed:meshHeading | pubmed-meshheading:16033261... | lld:pubmed |
| pubmed-article:16033261 | pubmed:meshHeading | pubmed-meshheading:16033261... | lld:pubmed |
| pubmed-article:16033261 | pubmed:meshHeading | pubmed-meshheading:16033261... | lld:pubmed |
| pubmed-article:16033261 | pubmed:meshHeading | pubmed-meshheading:16033261... | lld:pubmed |
| pubmed-article:16033261 | pubmed:meshHeading | pubmed-meshheading:16033261... | lld:pubmed |
| pubmed-article:16033261 | pubmed:meshHeading | pubmed-meshheading:16033261... | lld:pubmed |
| pubmed-article:16033261 | pubmed:meshHeading | pubmed-meshheading:16033261... | lld:pubmed |
| pubmed-article:16033261 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16033261 | pubmed:articleTitle | Control of protein-protein interactions: structure-based discovery of low molecular weight inhibitors of the interactions between Pin1 WW domain and phosphopeptides. | lld:pubmed |
| pubmed-article:16033261 | pubmed:affiliation | CNRS-University of Lille 2 UMR 8525, Institut Pasteur de Lille, Molecular Drug Discovery, 3 rue du Professeur Laguesse, 59000 Lille, France. | lld:pubmed |
| pubmed-article:16033261 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16033261 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:16033261 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16033261 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16033261 | lld:pubmed |
