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pubmed-article:16025524pubmed:abstractTextWe describe a new cast-immobilization protocol to induce muscle atrophy in the lower hindlimb muscles of mice. Bilateral cast immobilization for 2 weeks in a shortened position resulted in a significant loss of muscle size and strength in the soleus and extensor digitorum longus. The availability of a model of cast immobilization in mice may benefit future studies targeting genetic or cell therapy interventions of muscle atrophy in transgenic and mutant mice strains.lld:pubmed
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pubmed-article:16025524pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:16025524pubmed:articleTitleA model of muscle atrophy using cast immobilization in mice.lld:pubmed
pubmed-article:16025524pubmed:affiliationBrain Rehabilitation Research Center, Malcom Randall Department of Veterans Affairs Medical Center, Gainesville, Florida, USA.lld:pubmed
pubmed-article:16025524pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16025524pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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