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pubmed-article:16024114pubmed:abstractTextInhibition of repopulation and enhanced reoxygenation has been suggested to contribute to improvement of local tumour control after fractionated irradiation combined with inhibitors of the epidermal growth factor receptor (EGFR). The present study addresses this hypothesis in FaDu human squamous cell carcinoma. For this tumour model marked repopulation and incomplete reoxygenation during fractionated irradiation has previously been demonstrated. Furthermore, the anti-EGFR monoclonal antibody C225 has been shown to significantly improve the results of fractionated irradiation in this tumour.lld:pubmed
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pubmed-article:16024114pubmed:pagination162-7lld:pubmed
pubmed-article:16024114pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:16024114pubmed:articleTitleDecreased repopulation as well as increased reoxygenation contribute to the improvement in local control after targeting of the EGFR by C225 during fractionated irradiation.lld:pubmed
pubmed-article:16024114pubmed:affiliationDepartment of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Germany.lld:pubmed
pubmed-article:16024114pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16024114pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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