Linked Life Data

16014724

Source:http://linkedlifedata.com/resource/pubmed/id/16014724

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pubmed-article:16014724pubmed:abstractTextWe studied the participation of adrenal medulla (AM) chromaffin cells in hypercapnic chemotransduction. Using amperometric recordings, we measured catecholamine (CAT) secretion from cells in AM slices of neonatal and adult rats perfused with solutions bubbled with different concentrations of CO2. The secretory activity augmented from 1.74 +/- 0.19 pC/min at 5% CO2 to 6.36 +/- 0.77 pC/min at 10% CO2. This response to CO2 was dose dependent and appeared without changes in extracellular pH, although it was paralleled by a drop in intracellular pH. Responsiveness to hypercapnia was higher in neonatal than in adult slices. The secretory response to hypercapnia required extracellular Ca2+ influx. Both the CO2-induced internal pH drop and increase in CAT secretion were markedly diminished by methazolamide (2 microm), a membrane-permeant carbonic anhydrase (CA) inhibitor. We detected the presence of two CA isoforms (CAI and CAII) in neonatal AM slices by in situ hybridization and real-time PCR. The expression of these enzymes decreased in adult AM together with the disappearance of responsiveness to CO2. In patch-clamped chromaffin cells, hypercapnia elicited a depolarizing receptor potential, which led to action potential firing, extracellular Ca2+ influx, and CAT secretion. This receptor potential (inhibited by methazolamide) was primarily attributable to activation of a resting cationic conductance. In addition, voltage-gated K+ current amplitude was also decreased by high CO2. The CO2-sensing properties of chromaffin cells may be of physiologic relevance, particularly for the adaptation of neonates to extrauterine life, before complete maturation of peripheral and central chemoreceptors.lld:pubmed
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pubmed-article:16014724pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:16014724pubmed:year2005lld:pubmed
pubmed-article:16014724pubmed:articleTitleRat adrenal chromaffin cells are neonatal CO2 sensors.lld:pubmed
pubmed-article:16014724pubmed:affiliationDepartamento de Fisiología, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, E-41013 Seville, Spain.lld:pubmed
pubmed-article:16014724pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16014724pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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