| pubmed-article:16006134 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16006134 | lifeskim:mentions | umls-concept:C0033147 | lld:lifeskim |
| pubmed-article:16006134 | lifeskim:mentions | umls-concept:C0038590 | lld:lifeskim |
| pubmed-article:16006134 | lifeskim:mentions | umls-concept:C0285890 | lld:lifeskim |
| pubmed-article:16006134 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16006134 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16006134 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16006134 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16006134 | pubmed:dateCreated | 2005-11-21 | lld:pubmed |
| pubmed-article:16006134 | pubmed:abstractText | Changes in the expression of alpha-synuclein are likely to underlie its normal function as well as its role in pathological processes. The relationship between toxic injury and alpha-synuclein expression was assessed in the substantia nigra of squirrel monkeys treated with a single injection of MPTP and sacrificed 1 week or 1 month later. At 1 week, when stereological cell counting revealed only a small decrease (-10%) in the number of dopaminergic neurons, alpha-synuclein mRNA and protein were markedly enhanced. Increased alpha-synuclein immunoreactivity was evident at the level of neuronal fibers whereas nigral cell bodies were devoid of detectable protein. At 1 month post-MPTP, neuronal loss rose to 40%. Both alpha-synuclein mRNA and protein remained elevated but, noticeably, a robust alpha-synuclein immunoreactivity characterized a significant number of cell bodies. Neuromelanin granules are hallmarks of dopaminergic neurons in primates. Therefore, the number of alpha-synuclein-positive cells that also contained neuromelanin was counted throughout the substantia nigra. At 1 month, the vast majority of alpha-synuclein-immunoreactive neurons contained neuromelanin, and approximately 80% of the dopaminergic cell bodies that survived MPTP toxicity stained positive for alpha-synuclein. The results indicate that a single toxic insult is capable of inducing a sustained alpha-synuclein up-regulation in the primate brain. They support a direct relationship between neuronal injury and enhanced alpha-synuclein expression, and suggest that protein elevation within cell bodies may be a late feature of neurons that have endured a toxic stress. | lld:pubmed |
| pubmed-article:16006134 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16006134 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16006134 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16006134 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16006134 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16006134 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16006134 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16006134 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16006134 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16006134 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16006134 | pubmed:issn | 0969-9961 | lld:pubmed |
| pubmed-article:16006134 | pubmed:author | pubmed-author:McCormackAlis... | lld:pubmed |
| pubmed-article:16006134 | pubmed:author | pubmed-author:Di... | lld:pubmed |
| pubmed-article:16006134 | pubmed:author | pubmed-author:PurisaiMaya... | lld:pubmed |
| pubmed-article:16006134 | pubmed:author | pubmed-author:LangstonWilli... | lld:pubmed |
| pubmed-article:16006134 | pubmed:author | pubmed-author:JohnstonLouis... | lld:pubmed |
| pubmed-article:16006134 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16006134 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:16006134 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16006134 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16006134 | pubmed:pagination | 898-906 | lld:pubmed |
| pubmed-article:16006134 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:16006134 | pubmed:meshHeading | pubmed-meshheading:16006134... | lld:pubmed |
| pubmed-article:16006134 | pubmed:meshHeading | pubmed-meshheading:16006134... | lld:pubmed |
| pubmed-article:16006134 | pubmed:meshHeading | pubmed-meshheading:16006134... | lld:pubmed |
| pubmed-article:16006134 | pubmed:meshHeading | pubmed-meshheading:16006134... | lld:pubmed |
| pubmed-article:16006134 | pubmed:meshHeading | pubmed-meshheading:16006134... | lld:pubmed |
| pubmed-article:16006134 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16006134 | pubmed:articleTitle | Alpha-synuclein expression in the substantia nigra of MPTP-lesioned non-human primates. | lld:pubmed |
| pubmed-article:16006134 | pubmed:affiliation | The Parkinson's Institute, 1170 Morse Avenue, Sunnyvale, California 94089, USA. | lld:pubmed |
| pubmed-article:16006134 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16006134 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16006134 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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